We found that, on the amino acids level, the mutation rate is 80% in HVR1, the homology with Chinese consistent sequence) CCS is 42%-60%, moreover, the nonsynonymous substitutions is high than synonymous substitutions.

• 发现高变区有80%25的氨基酸位点发生变异，氨基酸水平上不同分离株与CCS的同源性在42%25-60%25之间，而且错义突变明显多于无义突变。