When in HBeAg positive chronic hepatitis B patients with nucleoside analogous antiviral therapy, there are two target as HBV DNA decline or HBeAg seroconversion, which target is more important?

• HBeAg阳性的慢乙肝患者使用核苷类药物进行抗病毒治疗，有两个目标需要达到，病毒含量下降或者HBeAg血清阴转，哪一个更加重要？