Wyeth, an American firm, led the charge with Prevnar, a pneumococcal vaccine, which in 2004 became the first vaccine to reach a billion dollars in sales.

• 美国惠氏（Wyeth）公司率先对定价模式进行了改革。2004年它推出的肺炎球菌疫苗Prevnar成为首个销售额突破10亿美元的疫苗产品。