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- The investigation suggests that Mar phenotype of Escherichia coli be determined by the levels of active efflux system acrAB gene expression, and the expression of acrAB gene should be regulated by mar operon. 本研究表明大肠杆菌acrAB表达水平决定了大肠杆菌多重耐药表型,mar可能调控acrAB的表达。
- Keywords Bifidobacterium;active efflux system;2;4-dinitrophenol;ciprofloxacin; 关键词双歧杆菌;主动外排系统;2;4-二硝基酚;环丙沙星;
- Multiple-antibiotic-resistant active efflux system gene identification and sequential analysis of Salmonella typhi 伤寒沙门菌多重耐药主动外排系统基因检测与序列分析
- Sequence analysis of multiple- antibiotic- resistant active efflux system gene acrAB of Salmonella typhi 伤寒沙门菌多重耐药acrAB全基因的检测及序列分析
- active efflux system 主动外排系统
- Expression of multidrug active efflux system acrAB-tolC genes in clinical isolated strains of Shigella 临床分离志贺菌属细菌主动外排系统acrAB-tolC基因的表达
- Objective: To investigate active efflux of drugs in clinical isolated strains of Escherichia coli. 目的:研究临床分离的大肠杆菌多重耐药株和敏感株中抗菌药物的主动外排系统。
- Objective To investigate the active efflux of fluoroquinolones in clinical isolated strains of Escherichia coli. 目的研究临床分离的大肠杆菌敏感株和多重耐药菌株体内的氟喹诺酮类药物积聚情况与耐药性的关系。
- The drug-resistance mechaniam of shigella caused by producing inactived enzyme,changing cell walls,target site structure and active efflux pump. 志贺菌的耐药机制主要是产生灭活酶、细胞壁的改变、主动外排以及作用靶位结构的改变。
- ESBLs,AmpC,VIM,IMP,OXA23,OXA-24 and outermembrane protein were detected. Reserpine synergistic inhibition test was used to study the active efflux mechanism. 检测ESBLs、AmpC酶、VIM、IMP、OXA-23和OXA-24产生及外膜蛋白表达情况,利血平协同抑制试验检测膜外排机制。
- Intestinal CYP3A4-mediated biotransformation and active efflux of absorbed drug by P-glycoprotein are major determinants of bioavailability of orally administered drugs. 肠CYP3A4介导的生物转化和P糖蛋白介导的药物主动泵出肠细胞是决定口服药物生物利用度的主要因素。
- Conclusion: There was active efflux of tetracycline and penicillin in clinical isolated strains of Escherichia coli, but the capability was less than in Mar strains. 结论:临床分离的敏感株中亦存在能泵出四环素和青霉素的主动外排系统,但其外排功能显著低于多重耐药株。
- Objective To study the mechanism of multiple-antibiotic-resistance in clinical isolates of Shigella and to detect the distribution and expression of active efflux pump gene acrAB-tolC. 目的研究志贺菌患者分离株的多重耐药机制。 方法检测志贺菌中有无主动外排系统acrAB-tolC结构基因acrAB-tolC在临床分离菌株中的分布;
- To investigate multiple-antibiotic-resistance mechanism in Escherichia coli, the distribution of active efflux pump gene, acrAB, were determined by PCR, Southern bolt, and its expressions by RT-PCR, in clinical strains of Escherichia coli. 为了研究临床分离多重耐药大肠杆菌的耐药机制,我们采用PCR和Southernblot检测大肠杆菌主动外排系统AcrAB结构基因acrAB在临床分离菌株中的分布并用RT-PCR测定其mRNA表达水平。
- To study the mechanism of multidrug resistance in c1inical isolates of Klebsiella pneumoniae and detect the dis-tribution and expression of active efflux pump gene acrAB, homologous to that in Escherichia coli. 目的:研究临床分离多重耐药肺炎克雷伯菌的耐药机制,检测肺炎克雷伯菌中有无类似大肠埃希菌主动外排系统AcrAB的结构基因acrAB的分布和表达。
- But discordance between the two methods existed in 8 (21.1%) cases (5E +P gp -, 3E -P gp +). E +P gp - suggested that non classic multidrug resistance (MDR1) mediated efflux system might exist in ANLL. 21.;1%25存在表达与活性分离(3例P?gp+E-,5例P?gp-E+),P?gp-E+提示非P?gp介导的排出活性在ANLL耐药中可能具有重要作用。
- The orient has been playing an active role in the world economy. 亚洲一直在世界经济中发挥积极作用。
- He is an active member of the school's stamp club. 他是学校集邮俱乐部的一名活跃会员。
- An active volcano may explode at any time. 活火山随时都有可能爆发。
- Is it wise to engage in active sports at your age? 我这样的年纪积极参加体育活动是否明智?