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- Despite a high morphological similarity, tumors with allelic loss on the short arm of chromosome 1 (1pLOH) are more chemosensitive than those without 1pLOH. 尽管两种肿瘤在形态学上极其相似,但是1号染色体短臂上等位基因丢失的肿瘤比没有丢失的药物敏感性要高得多。
- Objective To define finely the patterns of allelic loss at the FRA3B site in nasopharyngeal carcinoma(NPC) and to detect potential relationship between allelic loss,clinicopathologic features and Epstein-Barr Virus(EBV) infection. 目的研究鼻咽癌染色体脆性部位FRA3B区域的等位基因杂合性丢失(loss of heterozygosity,LOH)情况,并探讨LOH与鼻咽癌临床病理特征及EB病毒(Epstein-Barr virus,EBV)感染的关系。
- Allelic loss at the FRA3B site occurs frequently in NPC. This suggests that the region between D3S4103 and D3S4260 may represent a preferential molecular target in nasopharyngeal carcinogenesis. FRA3B脆性部位的LOH为鼻咽癌的频发事件,可能参与了鼻咽癌的发生发展,共同缺失区D3S4103-D3S4260可能是其优先作用的分子靶点。
- Hepatocarcinogenesis is strongly linked to increases in allelic losses, chromosomal changes,gene mutations, epigenetic alterations and alterations in molecular cellular pathways. 肝癌的形成与等位基因丢失,染色体改变,基因突变,分子细胞通路改变关系密切。
- Detailed allelic loss mapping on 7q32 in nasopharyngeal carcinoma 鼻咽癌染色体7q32区域微缺失的研究
- To investigate the significance of allele loss of DCC (deleted in colorectal cancer)gene in Chinese colorectal cancer patients. 目的:探讨DCC基因在结直肠癌中杂合性缺失情况及其意义。
- Precise map of allelic loss on chromosome 3p14 in nasopharyngeal carcinoma 鼻咽癌染色体3p14的精细等位基因缺失研究
- I commiserate with you on the loss of your mother. 你母亲逝世,我特向你慰问。
- How can we divert her thoughts from her sad loss? 我们怎样才能使他不再想到她可悲的损失?
- The loss of all his money embitter the old man. 失去全部的钱,使这位老人甚为痛苦。
- The loss of the ball game stir up much feeling. 球赛输了引起了极大的愤慨。
- The ship was wrecked and became a total loss. 船只失事,一切都损失了。
- The insurance company will recompense his loss. 保险公司将赔偿他的损失。
- His death is a lamentable loss of our work. 他的死对我们的工作来说是令人悲痛的损失。
- Loss of pressure had not registered on the dials. 刻度盘未记录压力下降。
- His costly mistake resulted in severe loss. 他的严重的错误导致了重大的损失。
- This loss led to the demise of the business. 这一损失导致了公司的倒闭。
- Her departure is a great loss to the orchestra. 她离去是管弦乐队的一大损失。
- She seemed fairly philosophical about the loss. 她对所受损失似乎很看得开。
- Artillery fire caused heavy loss. 炮火造成重大损失。