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- Antisense oligodeoxynucleotide technique was used to observe the role of CLC-3 in the effect of ET-1 on BCECs. 采用反义核酸技术,观察CLC-3基因在ET-1对体外培养牛角膜内皮细胞影响中的作用。
- Objective To study the effect of antisense oligodeoxynucleotide c-myc (c-myc ASODN) on anti-oxidation system in LEC induced by galactose. 目的探讨ASODN对半乳糖性白内障晶体上皮细胞(LEC)中抗氧化系统活力的影响。
- Aim: To observe if bcl-2 antisense oligodeoxynucleotide (ASODN) mediated by jetPEI-RGD improved effect on colon carcinoma cell line caco-2. 目的:观察聚乙烯亚胺(PEI)-整合素蛋白的配体(Arg-Gly-Asp, RGD)介导的bcl-2反义核酸(antisense oligodeoxynucleotide, ASODN)对结肠癌细胞caco-2的作用效果。
- Conclusion ATP7B antisense oligodeoxynucleotide increased the sensitivity of cisplatin in ovarian cancer cell line SKOV3ipl. 结论 ATP7B基因反义寡核苷酸能增加SKOV3ip1细胞对顺铂的敏感性。
- Objectives: To study the inhibitory effects of mouse telomerase RNA (mTR) antisense oligodeoxynucleotide(ASODN) on telomerase activity in rat spermatogonia. 目的 :探讨小鼠端粒酶RNA(mTR)基因的反义寡核苷酸 (ASODN)对体外培养的大鼠A型精原细胞端粒酶活性及其mTR亚基表达的影响。
- Poorly differentiated nasopharyngeal carcinoma (SUNE 1) cell line was cultured with Epstein Barr virus (EBV) BHRF1, DNase, thymidine kinase (TK) and nuclear antigen 1 (EBNA1) antisense oligodeoxynucleotide (ASO) for 48 h respectively. 用不同浓度的EB病毒 4种 (BHRF1、DNA酶、核抗原 1及胸苷激酶 )反义寡核苷酸片段 ,(antisenseoligodeoxynucleotide ,ASO)分别与含 10%25胎牛血清或不含胎牛血清的人低分化鼻咽癌细胞株 (SUNE 1)共同培养 4 8h。
- Antisense Oligodeoxynucleotide Liposomes 反义寡核苷酸脂质体
- Cyclin D3 antisense oligodeoxynucleotides were used in in vitro culture study. 用反义技术和流式细胞术研究周期蛋白D3在白血病细胞增殖中的作用。
- c-myc antisense oligodeoxynucleotide 反义c-myc寡核苷酸
- ObjectiveTo investigate the influence of STAT3 antisense oligodeoxynucleotides (ASO-STAT3) on radiosensitivity of B16 cells. 目的探讨反义STAT3转染鼠恶性黑色素瘤B16细胞后,肿瘤细胞辐射敏感性的变化。
- AIM To investigate the factors affecting transfection efficiency of antisense oligodeoxynucleotides (ASON) by cationic fusogenic liposome (CFL). 目的研究阳离子膜融合脂质体(CFL)介导反义寡核苷酸(ASON)的细胞转染效率及影响因素。
- The antisense oligodeoxynucleotides (ASODN) targeting VEGF-C was designed and its effect on VEGF-C gene expression in vitro experiments was observed. 设计合成VEGF-C反义脱氧寡核苷酸(ASODN),体外实验观察其对VEGF-C基因表达的影响;
- Objective: To investigate the difference in inhibiting synoviocytes proliferation by 2 c-myc antisense oligodeoxynucleotides(AS-ODN) sequences,myc-AUG AS-ODN and myc-CRD AS-ODN. 目的:研究针对c-myc mRNA不同位点的两种反义寡脱氧核苷酸序列(AS-ODN):myc-AUG AS-ODN,myc-CRD AS-ODN,对类风湿滑膜细胞增殖的抑制作用。
- Objective To investigate the effect of Bcl-2 antisense oligodeoxynucleotides (ASODN) on the cell proliferation and Bcl-2 expression in bile duct carcinoma cell line QBC939. 目的:观察Bcl-2反义硫代磷酸寡脱氧核苷酸(ASODN)对人胆管癌QBC939细胞的作用及对Bcl-2蛋白表达的影响。
- Objective To investigate the efficacy of autologous bone marrow transplantation(ABMT) for patients with chronic myelogenous leukemia(CML) after in vitro purging of the graft with bcr/abl antisense oligodeoxynucleotides(AS ODN). 目的 观察bcr/abl反义寡核苷酸 (AS ODN)净化后自体骨髓移植 (ABMT)治疗慢性粒细胞白血病 (CML)的疗效。
- Objective To study the antitumor effects of Curcumin(Cur) combined with bcr/abl antisense Oligodeoxynucleotides(ASODN) on Chronic Myelogenous Leukemia(CML)cell line K562 and to explore its antitumour characters and mechanism . 目的 研究姜黄素(Cur)与bcr/abl反义核酸联合应用对慢性粒细胞白血病(CML)K562细胞株的抗肿瘤作用,探讨Cur抗CML的作用特点与机制。
- AIM:To investigate inhibition of the discoidin domain receptor(DDR)expression of keloid fibroblast by the phosphorothioate-modify and the liposome-encapsulation antisense oligodeoxynucleotides(ASODN)and its effect on keloid collagen suppression. 目的:观察硫代修饰和脂质体包埋的反义寡核苷酸(ASODN)抑制瘢痕疙瘩成纤维细胞圆盘状受体基因表达及其对瘢痕疙瘩胶原抑制的影响。
- Antisense oligodeoxynucleotides (ASODNs) are synthetic ODNs, which hybridize with specific gene segments modulating the expression of these genes at transcriptional and translational stages. 反义寡核苷酸(ASODN)是一段能与特定基因结合并抑制其表达的人工合成的脱氧寡核苷酸链,可在转录、翻译水平调节相关基因表达。
- Effects of metallothionein antisense oligodeoxynucleotide on the biological behaviors of HeLa cervical cancer cell line 金属硫蛋白反义寡核苷酸对子宫颈癌细胞增殖及凋亡的影响
- Effects of survivin antisense oligodeoxynucleotide on the growth of colorectal carcinoma transplanted in the nude mice 生存素反义核酸对裸鼠皮下种植结肠癌细胞的作用