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- Genotoxicity study is to study the genotoxicity and thepotential carcinogenesis effect of the test article. We can make such studies as Ames test, chromosomal aberration test, micronucleus test. 遗传毒性试验是研究受试物的遗传毒性及潜在的致癌作用。本中心可开展项目。包括Ames试验、染色体畸变试验、微核试验。
- Chromosomal aberration test in vitro 体外培养染色体畸变试验
- Objective: Traditional Ames test, in vitro mammalian chromosome aberration test, single cell gel electrophoresis assay have been used widely in monitoring chemical toxicity. 目的:传统的Ames实验、体外哺乳动物细胞染色体畸变实验、单细胞凝胶电泳实验已广泛用于化学品毒性的监测,但用于综合评价化学品的遗传学毒性还不够完善。
- MATERIAL AND METHODS: Chromosome aberration test,micronucleus test of bone marrow cell and sperm shape abnormality test in mice were used in this study. 材料与方法:采用小鼠睾丸染色体畸变试验,小鼠骨髓微核实验以及小鼠精子畸形实验方法。
- The results of Ames and micronucleus tests were negative, but the result of chromosome aberration test was positive. 风湿平Ames试验、小鼠骨髓细胞微核试验结果均为阴性; CHL细胞染色体畸变试验结果为阳性,经过S9代谢活化后致突变作用降低。
- Methods The micronucleus test of bone marrow cells, chromosome aberration test of bone marrow cells, sperm shape abnormality test in mice were carried out and the results were analyzed. 方法采用小鼠骨髓细胞微核试验、小鼠骨髓细胞染色体畸变试验、小鼠精子畸形试验进行观察。
- Spermatocyte chromosome aberration test 精母细胞染色体畸变试验
- spermatogonial chromosomal aberrations test 睾丸精母细胞染色体畸变试验
- CHL chromosomal aberration test CHL细胞染色体畸变试验
- chromosomal aberration test 染色体畸变试验
- In Ames test, micronucleus and chromosomal aberration assay BaCl2 showed negative results. Ames试验、微核试验和染色体畸变分析均为阴性结果。
- Induced effects of the in vivo derivatives of sulfur dioxide on chromosomal aberration in CHL cells. 二氧化硫体内衍生物诱发CHL细胞染色体畸变效应
- Hybridization in situ technique was employed to detect the chromosomal aberration in tumor tissues. 本实验用原位杂交技术检测几种肿瘤组织的染色体畸变。
- Keywords Aconitum Carmichaeli;Cyclophosphamide;Micronucleus Test;Sister Chromatid Exchange Test;Chromosome Aberration Test;Processing of Traditional Chinese Crude Drugs; 川乌;环磷酰胺;微核实验;姊妹染色单体交换实验;染色体畸变实验;中药炮制;
- Abstract Aneuploidy in human population is a serious genetic problem.The major cause of this numerical chromosomal aberration is non - disjunction. 摘要 在人类群体中非整倍性是个严重的遗传问题。
- Objective To investigate the clinical significance of chromosomal aberration of low dose professional radiation for workers in radiology departments. 摘要目的：探讨长期小剂量照射下放射工作人员染色体畸变的临床意义。
- The results demonstratethat the rate of chromosomal aberration,blood lead. blood copperand blood zinc levels between the two groups are all significantly dif-ferent (P<0.01). 发现两组间的染色体畸变率、血铅、血铜、血锌均有高度显著性差异(P<0.;01)。
- The molecular mechanism for chromosomal aberration and micronuclei induced by holmium ions was most probably DNA breakage to root-tip c ells of vicia faba. 钬离子诱导蚕豆根尖细胞染色体畸变和微核产生的分子机制主要为DNA断裂作用。
- chromosome aberration test 染色体畸变试验
- Conclusion Sauropus androgynus has certain genetic toxicity of chromosomal aberration induction and its molecular mechanism needs further investigation. 结论守宫木具有一定的诱发染色体畸变的遗传毒性。
