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- To establish time-efficient and sensitive method for detection of the methylation of FMR1(fragile X mental retardation)and XIST(X chromosome inactivation)genes,genomic DNA was deaminated by sodium bisulfite. 建立一种快速、灵敏的检测脆性X智障基因(fragile X mental retardation;FMR1)、X染色体失活基因(Xchromosome inactivation;XIST)甲基化的方法.
- Fragile X mental retardation protein 脆性X智力低下蛋白
- fragile X mental retardation protein (FMRP) 脆性X智力低下蛋白(FMRP)
- fragile X mental retardation(FMR) 脆性X智力低下
- Keywords fragile X syndrome;fragile X mental retardation protein;microtubule associated protein 1 B;mice; 脆性X综合征;脆性X智能低下蛋白;微管相关蛋白1B;小鼠;
- fragile X mental retardation 脆性X综合征
- Obejective To discuss the relationship between the congenital mental retard and the FMR-1(fragile X syndrome mental retardation genel). 目的探讨先天性智力低下与脆性X综合征智力低下基因1(Fragile X mentalretardation gene 1,FMR-1)关系。
- Objective:To investgate the possibility of reactivating fragile X mental retardation-1 gene(FMR1) by cyclic adenosine monophosphate(cAMP). 目的探讨环磷酸腺苷(cAMP)对脆性X智力低下一号封闭基因(FMR1)再激活作用的可能性。
- fragile X chromosome mental retardation syndrome 脆性X染色体智力障碍综合征
- Objective To study the influence of defection of Fragile X mental retardation-1 gene (FMR1) on cyclic adenosine monophosphate (cAMP) and to discuss its mechanism. 目的 探讨脆性X智力低下一号基因 (FMR1)表达缺失对环磷酸腺苷 (cAMP)的影响及其机制。
- fragile X mental retardation- 1 脆性X综合征致病基因
- A score below 70 may indicate mental retardation. 如果分数低于70可能表明智力迟钝。
- The mental retardation is correlative with the chromosome aberration and the fragile site expression rate. 提示精神发育迟滞与染色体的畸变率和脆性部位的表达率有一定的相关性。
- Conclusion: The mental retardation is correlative with the chromosome aberration and the fragile site expression rate. 结论:提示精神发育迟滞与染色体的畸变率和脆性部位的表达率有一定的相关性。
- One example is the triplet expansion repeat mutations which can cause fragile X syndrome or Huntington's disease. 第一个特性是这种遗传疾病是由得病的母亲传给儿子与女儿。
- The state or condition of being an idiot;profound mental retardation. 智力障碍处于痴呆的状态;极其严重的智力障碍
- The state or condition of being an idiot; profound mental retardation. 智力障碍处于痴呆的状态;极其严重的智力障碍。
- Objective To discuss the mechanism of intracellular cyclic adenosine monophosphate (cAMP) level depression in fragile X syndrome. 目的 探讨脆性X综合征细胞内环磷酸腺苷 (cAMP)降低的机制。
- Down syndrome is the most common genetic cause of mental retardation. 唐氏综合症是最常见的导致智力迟缓的基因原因。
- Her younger daughter was mentally retarded. 她的幼女是一个弱智儿童。