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- Glutamate receptors can be divided into two major classes: AMPA and NMDA receptors. 谷氨酸受体主要可以分为两大类：AMPA受体和NMDA受体。
- There are two classes of glutamate receptors: ionotropic(iGluRs) and metabotropic(mGluRs). 谷氨酸受体有促离子型受体和促代谢型受体两种类型。
- Glutamate is a primary excitatory neurotransmitter and responsible for mediating a broad range of nervous system functions through glutamate receptors. 目的谷氨酸是一种重要的兴奋性神经递质,通过体内的谷氨酸受体参与神经系统多种功能的调节。
- The ionotropic glutamate receptor antagonists D-AP5 and CNQX could not fully block the action of ACM. 离子型谷氨酸受体拮抗剂D-AP5和CNQX不能完全阻断条件培养基的作用。
- Agents that directly activate “AMPA-type” glutamate receptors, which work in concert with NMDA receptors, are also under active investigation. 另外有一种称为AMPA型的麸胺酸受体，可与NMDA受体携手合作；直接刺激AMPA受体的药剂，目前也正积极研究当中。
- DAO is expressed in the human brain, where it oxidizes D-serine, a potent activator of NMDA glutamate receptor. DAO表达在人的大脑中，它可以氧化D-丝氨酸，后者则是一个强力的NMDA谷氨酸受体激活剂。
- Glutamate receptors are divided into two subtypes,i.e.,ionotropic glutamate receptor(iGluR)and metabotropic glutamate receptor(mGluR). 谷氨酸是中枢神经系统最主要的兴奋性神经递质,其受体共分为两大类:离子型及代谢型,两者均广泛分布于中枢神经系统。
- For the past year, I have been working with a subset of neuronal glutamate receptors via voltage clamping on Xenopus oocytes. 过去的一年里，我一直在研究在蛙卵上神经元谷氨酸受体的一个子集通过电压箝位的现象。
- The glutamate receptor interacting protein 1 (GRIP1) is a scaffolding protein in postsynaptic density (PSD), tethering AMPA receptors to other signaling proteins. GRIP1可以直接与AMPA受体相互作用并将之与其它信号蛋白联结在一起。
- AIM To study the changes and effects of metabotropic glutamate receptor subtype 2 (mGluR2) in diffuse brain injuries (DBI) coupled with secondary brain insults (SBI) in rats. 目的 研究弥漫性脑损伤 (diffusebraininjury;DBI)及其合并二次脑损伤 (secondarybraininsults;SBI)后大鼠脑皮层代谢性谷氨酸受体 2亚型 (mGluR2 )的变化及其意义 .
- AIM To study the changes and effects of metabotropic glutamate receptor subtype 4 (mGluR4) after diffuse brain injuries (DBI) coupled with secondary brain insults (SBI) in rats. 目的 研究弥漫性脑损伤 (DBI)及其合并二次脑损伤 (SBI)后大鼠脑皮层代谢型谷氨酸受体亚型 4(m Glu R4)的变化及意义 .
- Howlett found the fruit fly's metabotropic glutamate receptor (DmGluRA) gene, when mutated, increased the excitability of the neuron by preventing PI3K from doing its job. 赫尔特发现当果蝇的亲代谢性谷氨酸盐受体基因发生突变时，将通过阻止PI3K的作用来增加神经元的兴奋性。
- Tra2 is an SR-like protein that has several isoforms and, regulates the alternative pre-mRNA splicing of many important genes, including the glutamate receptor. Tra2（splicing factor Transformer-2）是一种SR相关蛋白的选择性剪接因子，有多种亚型，Tra2参与包括谷氨酸受体在内的很多重要基因前体mRNA的选择性剪接。
- During both in vivo and in vitro development, CGC depend on the activity of the NMDA glutamate receptor subtype for survival and full differentiation [3]. 在体内和体外发育过程中，小脑颗粒细胞依赖于N-甲基-D-天冬氨酸(NMDA)谷氨酸盐受体亚型的活性而生存和完全分化。
- Down-regulateon of glutamate receptor 2 mRNA could lead to formation of GluR2-lacking, Ca2+-permeable AMPA receptors and increased toxicity of endogenous glutamate, which may be involved in the mechanisms of thedelayed neuronal death. 结论 我们的研究显示，成年大鼠癫痫持续状态后海马神经元发生的是选择性的、迟发性的损伤，而AMPA受体的亚单位谷氨酸受体-2的下调形成了Ca~(2+)渗透性的AMPA受体，增加了内源性谷氨酸的兴奋毒性，可能参与了迟发性神经元损伤的机制。
- What we found was that glutamate, which is released due to neuronal activity, feeds back onto metabotropic glutamate receptors on the same neurons that released it in the first place, he said. 他说我们发现神经兴奋时释放的谷氨酸反馈作用于早先释放谷氨酸同一个神经元的亲代谢性谷氨酸盐受体。
- Glutamate receptors are the primary excitatory neurotransmitter receptors in the central nervous system and divided into two major categories: ion tropic receptors and metabotropic receptors. 谷氨酸是通过谷氨酸受体传递兴奋性信息的,谷氨酸受体是中枢神经系统主要的兴奋性神经受体,分为离子型受体与代谢型受体。
- By binding to certain glutamate receptors, D-cycloserine selectively enhances extinction, suppressing the effects of conditioned associations such as anxiety, addiction and phobias. 通过与特定的谷氨酸酯结合，D-cycloserine选择性的增强了遗忘，抑制了由于焦虑，上瘾和恐惧所带来的效果。
- More precisely, they block the action of a form of glutamate receptor known as the NMDA receptor, which plays a critical role in brain development, learning, memory and neural processing in general. 说得更精确些，这些药物阻断了一种叫做NMDA型的麸胺酸受体，该受体对于大脑的发育、习、忆以及一般的神经活动都扮演著举足轻重的角色。
- The N-methyl-D-aspartate receptor (NR), a subtype of ion-tropic glutamate receptor, provides sites for phosphorylation and for channel blocking. NRs are composed of NR1 and NR2A-D subunits. 现已发现NMDAR至少存在7个亚单位,即NR1亚单位、4种NR2亚单位(分为NR2A、NR2B、NR2C和NR2D)以及2种NR3亚单位。
