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- Objective To study the security of Ibutilide fumarate Injection. 目的评价富马酸伊布利特注射液的安全性。
- Objective:To study preparation and quality control of ibutilide fumarate for injection. 目的:制备注射用富马酸伊布利特并建立其质量控制方法。
- Methods The reaction on Guinea pig irritability,hemolysis and stimulation on blood vessel of rabbit by Ibutilide fumarate Injection were studied. 方法对富马酸伊布利特注射液进行了过敏性、溶血性及血管刺激性试验。
- In 2007, the first devoted to the treatment of atrial flutter, atrial fibrillation medicine "Fengyuan Ibutilide Fumarate Injection" exclusive listing, filled the gap. 2007年，国内第一个专门用于治疗房扑、房颤的特效药“丰原富马酸伊布利特注射液”独家上市，填补了国内空白。
- The antiarrhythmic drug ibutilide fumarate was synthesized from aniline by methylsulfonylation, Friedel Crafts reaction, condensation, reduction and salification with an overall yield of 44%. 以苯胺为起始原料,经甲磺酰化、傅克反应、缩合、还原和成盐反应等5步合成了抗心律失常药富马酸伊布利特,总收率44%25(以甲磺酰苯胺计)。
- Keywords ibutilide fumarate;antiarrhythmic agent;synthesis; 富马酸伊布利特;抗心律失常药;合成;
- Ibutilide fumarate Injection 富马酸伊布利特注射液
- ibutilide fumarate 富马酸伊布利特
- Ibutilide concentration-dependently effect ICa-L. 伊布利特可能呈浓度依赖性影响心室肌细胞L型钙电流(ICa-L)活性。
- Tiamulin Fumarate Soluble Granules 45%(Tiamutin? 延胡索酸泰妙菌素可溶性颗粒45%25(枝原净?
- Objective To improve the prescription of Clemastine Fumarate Tablets. 目的改进富马酸氯马斯汀片剂的工艺处方。
- Recent methods of dimethyl fumarate synthesis are reviewed in this article. 本文对近年来富马酸二甲酯的合成方法进行了评述。
- The pharmacology,pharmacokinetics,clinical uses and side Affects of ibutilide,a new antiarrhythmic drug,were reviewed. 通过查阅近几年文献，综述了伊布利特的药理作用、药代动力学、临床应用和不良反应。
- AF/AFL were converted in 10 of 16 patients(62.5%)in ibutilide group and in 4 of 15 patients(26.7%)in propafenone group(P<0.05). 转复率:伊布利特组62.;5%25(10/16);普罗帕酮组26
- The fumarate ion participates in several important metabolic pathways, e.g. the Krebs cycle, purine pathways, and the urea cycle. 延胡索酸分别参与多种重要的代谢途径，如卡尔文循环、嘌呤途径和尿素循环。
- In this article,we review the pharmacology,clinical trials and present problems of combined use of ibutilide and class IC antiarrhythmic agents. 现对伊布利特与Ic类药物合用的药理基础、临床试验结果及问题和展望等方面作一综述。
- In this test,Dimethyl fumarate, Metyl topsin and Sodium dehydrogene acetate were used in the antiseptic treatment during the storage. 本项研究中还试用了富马酸二甲酯、甲基脱布津、脱氢醋酸钠三种防腐剂对抑制葛根采后霉变进行了初步研究。
- As a result, the yield of mono-butyl fumarate(MBF), and the yield of mono-cyclohexyl fumarate (MCHF) is about 88.4%. 富马酸单丁酯(MBF)产率为89.;6%25，富马酸单环己酯(MCHF)产率为83
- However the overall conversion rate on AFL and AF of the ibutilide group was 61.7%, significantly higher than that of the propafenone group (41.9%,P<0.05). 两组房颤和房扑总转复率的差异有统计学意义(伊布利特组和普罗帕酮组分别为61·7%25和41·9%25;P<0·05)。
- Properties of dimethyl fumarate were briefly introduced which included physical propreties and action mechanisms. 简要介绍了富马酸二甲酯的性质,包括物理性质、作用机理。
