methylnicotinic acid as a intermediate of rupatadine,was synthesized from 3,5-dimethylpyridine by the reaction of sective oxidation with KMnO4.

• 以3,5-二甲基吡啶为原料,用高锰酸钾选择性氧化,合成抗过敏性药物卢帕他定中间体5-甲基烟酸。