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- In order to search new compounds with higher antitumor activities and lower toxicity,mutual prodrug of silatrane derivatives and 5-fluorouracil were designed on the basis of association principle. 杂氮硅三环具有免疫增强和抗肿瘤作用,依据药物设计的拼合原理设计了杂氮硅三环与5-氟尿嘧啶结合的协同前药,以期寻找高效低毒的抗肿瘤化合物。
- Keywords mutual prodrug;neuropathic pain;drug synthesis; 互联体前药;神经病理性疼痛;药物合成;
- Objective: Mutual prodrugs of gabapentin and pergabalin were synthesized for relieving neuropathic pain. 目的:合成具有抗神经病理性疼痛的加巴喷丁和普瑞巴林的互联体前药化合物。
- Three batyl alcohol derivates were synthesized from fatty acid divinyl ether with batyl alcohol, and then six mutual prodrugs were obtained by further enzymatic transetherification with nucleoside drug (ddI or acyclovir) in nonaqueous organic solvents. 论文研究了非水介质中酶促合成核苷和鲨肝醇的复合药物的方法; 以脂肪酸二乙烯酯利鲨肝醇获得三种鲨肝醇的单乙烯酯,进一步与去羟肌苷和阿昔洛维两种核苷类药物反应得到6种含有核苷和鲨肝醇的复合药物;
- It will be to our mutual advantage to work closely. 密切合作将为我们业务的顺利开展提供保证。
- My friend and I have mutual enthusiasm for music. 我和我的朋友对音乐有着共同的爱好。
- We found that we had a mutual friend. 我们发现我们有一个共同的朋友。
- Mutual understanding is essential to friendship. 相互理解对友谊至关重要。
- The party was rent with mutual strife. 该党因互相倾轧而四分五裂。
- mutual prodrug 互为前体药物
- Wanting mutual support, victory is impossible. 没有互相支援就不可能胜利。
- Expand trade between us will be to our mutual benefits. 扩大我们之间的贸易将对我们双方有利。
- Chiyoda Mutual Life Insurance Co. 千代田寿险公司(日本)
- So it should be a promising prodrug. 为以后研究更为有效的GPX模拟酶奠定了基 Reactive oxygen species (ROS) are products of the normal metabolic activities of aerobic living organism and are produced in response to various stimuli.
- The country tried to confederate itself with other countries for mutual safety. 这个国家，为了共同安全，曾试图使自己与别的国家结盟。
- Let's give mutual support and inspiration to each other. 让我们互相支持，互相鼓励。
- We should confer with them on matters of mutual concern. 我们应该跟他们就共同关心的问题进行商讨。
- I believe the measure will redound to our mutual benefit and reputation. 我相信这项措施将有助於我们共同的利益和名誉。
- A mutual clarification of misunderstandings; a reconciliation. 和解为消除误解而进行的相互说明; 和解
- He aims to encourage mutual understanding. 他的目的在于增进相互了解。
