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Genetically Modified Myeloma Cell Vaccine Inducing Antitumor Immune Response in vivo 多发性骨髓瘤基因修饰瘤苗诱导体内抗肿瘤反应的实验研究
myeloma cell vaccine 骨髓瘤细胞疫苗
Conversely, the tumors might mutate to “escape” the immune onslaught engendered by a dendritic cell vaccine. 反之，肿瘤可能也会产生突变，因而躲过树突细胞疫苗引发的免疫攻击。
Blimp-1 could help 2ME2 induce differentiation on myeloma cell lines by downregulating pax-5 mRNA and upregulating xbp-1 mRNA. Blimp-1可通过抑制pax-5 mRNA表达水平,从而提升xbp-1mRNA表达水平,促进骨髓瘤细胞分化。
The results showed that compared with myeloma cell, marked changes were not observed in hybridoma cell in cell energy and cell appearance. 结果表明，与凯骨髓瘤细胞相比，杂交瘤细胞的细胞活力和细胞形态无明显变化；
The chromosome number of post-fused hybridoma cell was near to the cumulative chromosome number of splenic cell and myeloma cell. 当脾细胞与凯骨髓瘤细胞融合形成杂交瘤细胞后，其染色体数目接近两亲本细胞染色体数目之和。
Conversely, the tumors might mutate to "escape" the immune onslaught engendered by a dendritic cell vaccine. 反之，肿瘤可能也会产生突变，因而躲过树突细胞疫苗引发的免疫攻击。
Aim: To study the adjuvant effects of CpG motif in vitro on human esophageal cancer Eca-109 cell vaccine. 目的:探讨CpG基序在人食管癌Eca-109细胞疫苗中的佐剂效应。
We determined the serum ANA autoantibody of 253 patients, using the BAB/C mouse myeloma cell NS-1 as antigen and applying the technique of indirect fluoro-immunoassay. 本文应用小鼠（BAB/C）骨髓瘤细胞（NS－1）细胞为抗原，采用间接免疫荧光技术检测了253例血清标本中的抗核抗体（ANA），并与鼠肝细胞为载体法进行了比较。
The average numbers of chromosomes of the two hybridoma cell lines were 98 and 101 which were consistent with the total chromosome numbers of spleen cell and myeloma cell. 染色体计数分析结果显示，两株杂交瘤细胞的平均染色体数分别为98和101，在脾细胞与 SP2/0 细胞染色体数之和的范围之内；
Objective:To illustrate the effect on myeloma cells with TK gene by GCV. 目的:探讨更昔洛韦对转染TK基因的骨髓瘤细胞生长的抑制作用。
These results suggested that HSP70-peptide complex played a very important role in the course of immunoprotective antitumor effects induced by elemene combo-tumor cell vaccine. 这些结果提示，HSP70_肽复合物在榄香烯复合瘤苗诱导的抗瘤免疫保护效应中起十分重要的作用。
Conclusion The purified cell wall of Corynebacterium parvum maintained the activity but eased the adverse reaction of whole cell vaccine of Corynebacterium parvum. 结论纯化的短棒状杆菌细胞壁不仅保留了全菌体制剂所具有的活性，而且明显减轻了局部的刺激作用。
Objective To assess the influence of cysticercus cellulosae cell vaccine on immunization in pregnant sows, piglets with maternal antibody and normal piglets. 摘要目的观察猪囊尾蚴细胞疫苗对妊娠母猪、具有母源抗体的仔猪和正常仔猪的影响。
The spleen cells from the BALB/C mouse immunized with the type B toxoid were fused with aNS-1 myeloma cell line. 以B型肉毒类毒素免疫BALB/C小鼠,取脾细胞与NS-1骨髓瘤细胞进行细胞融合。
During the process of industrialized production of primary hamster kidney cell vaccine (PHKCV),We determined the virulence and potency and analyzed the data. 探讨在原代地鼠肾细胞组织培养的狂犬病疫苗(PHKCV)工业化生产中,对病毒滴度与疫苗效力进行测定,并对数据进行分析。
Objective Analyzing biological function of ATL, an autoreactive T cell line from lupus-prone mice BXSB to study the feasibility of TCV (T cell vaccine) in the SLE. 目的探讨自身反应性T细胞系过继转移对受体小鼠免疫应答的影响 ,为在BXSB小鼠探索T细胞疫苗的可行性奠定基础。
Objective To assess the influence of cysticercus cellulosae cell vaccine on immunization in pregnant sows,piglets with maternal antibody and normal piglets. 目的观察猪囊尾蚴细胞疫苗对妊娠母猪、具有母源抗体的仔猪和正常仔猪的影响。
The cTnI was used to immunize Balb/c mice by route method. The spenocytes were fused with SP2/0 myeloma cell lines. Six hybridoma cell lines,secreting stably McAbs to cTnI antigen have been obtained and screened. 方法 :应用cTnI免疫Balb/c小鼠 ,取脾细胞与SP2 /0骨髓瘤细胞进行细胞融合筛选 ,获得分泌高效价抗cTnI抗体细胞株 6株。
Methods:By using RV HSV TK gene system and MTT technique, the growth inhibited effect on myeloma cells with TK gene by GCV were analysed. 方法:应用缺陷型反转录病毒介导的TK基因系统(RV-HSV-TK)转染骨髓瘤细胞,采用细胞增生实验(MTT法),研究更昔洛韦对转染TK基因的骨髓瘤细胞株的抑制作用。