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- The Nuclear Receptor Coactivator AIB1 Mediates Insulin-like Growth Factor I-induced Phenotypic Changes in Human Breast Cancer Cells. 主要学术内容和意义:核受体辅激活子AIB1(乳腺癌中扩增)在人类乳腺癌细胞中通过雌激素信号过表达。
- Until now, many nuclear receptor coactivators were cloned including RIP 140, CBP/P300, SRC/pl60, CARM-1, TRAP/DRIP, and the newly discovered SRA (a small RNA molecular serving as a coactivator). 迄今已分离鉴定出大量的核受体辅活化子,如RIP140、CBP/P300、SRC/p160家族、CARM-1、TRAP/DRIP等,包括最近发现的SRA(一种有辅活化子功能的RNA)。
- Identification of Troponin I 2 As a Nuclear Receptor Coactivator 肌钙蛋白I2作为核受体辅活化子的鉴定
- Keywords endometrial neoplasms;nuclear receptor coactivator;reverse transcriptase polymerse chain reaction; 子宫内膜肿瘤;核受体共激活因子;逆转录聚合酶链反应;
- Keywords proline-rich nuclear receptor coactivator(PNRC);luciferase assays;promoter characterization; 富含脯氨酸核受体辅活化子(PNRC);荧光素酶活性检测;启动子鉴定;
- Keywords proline-rich nuclear receptor coactivator(PNRC);nuclear factor Y(NFY);regulatory factors that bind to the X box(RFX1);transcriptional regulation; 富含脯氨酸核受体辅活化子(PNRC);核因子Y;调节因子X1;转录调节;
- nuclear receptor coactivator 核受体共激活因子
- Objective To investigate the effect of steroid receptor coactivator family in initiation, development, treatment and prognosis of breast cancer. 摘要目的探讨类固醇受体辅活化因子家族在乳腺癌发生、发展、治疗、预后等方面的作用。
- Probably the new nuclear receptor ligands such as FXR ligand will be the next compound. 新的核受体配体很可能成为下一代化合物,如FXR配体。
- Objective To determine the ETO interaction domain of nuclear receptor co repressor (N CoR) for abolishing the biological function of AML1 ETO. 目的 为消除急性髓系白血病标志基因AML1/ETO的活性 ,确定核受体辅助抑制因子(nuclearreceptorco repressor,N CoR)与ETO基因相互作用的活性部位。
- Androgen receptor belongs to the nuclear receptor superfamily and is a ligand-dependent transcription regulator, which can be activated by androgen. 雄激素受体属于核受体超家族,为配体依赖性基因转录因子,与雄激素结合后被激活。
- The androgen receptor(AR)belongs to the steroid receptor family,which is a part of the large nuclear receptor superfamily. 雄激素受体(AR)属于核受体超家族中的类固醇受体。
- This article reviewed the advance in study on nuclear receptor mediating cell proliferation differentiation and apoptosis. 现就核受体介导细胞增殖、分化与凋亡的作用机制研究进展做一综述。
- The discovery that the HR protein is a nuclear receptor corepressor indicated that HR function in hair cycling is by regulating gene expression. HR蛋白是细胞核受体辅阻遏物的发现证明HR蛋白是通过在毛发周期中调节基因表达来发挥作用的。
- In this article, we reviewed the research advancement in the signal transduction pathway of nuclear receptor and membrane receptor during the activation of hepatic stellate cells. 本文就肝星状细胞激活过程中一些重要的膜受体、核受体信号转导途径及其研究进展作一综述。
- Recent work linking these pathways in epithelial stem cell differentiation has come from studies analyzing the in vivo function of the nuclear receptor corepressor, Hairless (HR). 近来的有关表皮干细胞分化的途径的工作基于分析细胞核受体辅阻遏物HR的体内作用的研究。
- Steroid receptor coactivator - 3 类固醇受体辅活化子-3
- Abstract :Nuclear receptor (NR) is a ligand-dependent transcriptional factor which plays an important role in the metabolism of xenobiotics and endobiotics. 摘 要 :核受体是一种配体依赖性转录因子,在外源性物质和内源性物质的代谢中具有重要作用。
- Steroid receptor coactivator 3 gene 甾体类受体共激活因子3基因
- Methods The literatures in recent years which have related to the effect of steroid receptor coactivators in breast cancer are reviewed. 方法对近年来有关类固醇受体辅活化因子家族成员在乳腺癌中作用研究进展的文献进行综述分析。