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- polyketide synthetas 聚酮合成酶
- It is useful for discovery of novel fungal polyketide synthase gene clusters. 本文综述了近五年来建立的几种分离真菌聚酮合酶基因的方法。
- Besides, these compounds have the same character that all can be transformed to precursors of polyketide biosynthesis. 所以聚酮途径被认为是红曲色素合成的主要途径。
- Keating, T. A., And C. T. Walsh. "Initiation, Elongation, and Termination Strategies in Polyketide and Polypeptide Antibiotic Biosynthes. (聚酮类与多肽类抗生素生物合成的起始,延长及终止策略)。
- Polyketide synthases catalyze the synthesis of complex natural products including macrolide antibiotics from simple precursors such as propionyl-CoA and methylmalonyl-CoA. 聚酮合成酶能够合成包括许多大环内酯类抗生素在内的聚酮类天然产物,它的结构和功能的模块性为组合生物合成的产生和发展奠定了基础。
- Characteristics of filamentous fungal polyketide synthetase and isolation and identification of their gene coding as well as their pathway engineering were reviewed. 综述了丝状真菌聚酮体合成酶的特性及其编码基因的分离、鉴定和途径工程。
- The structural and functional modularity of these multienzyme systems has raised the possibility that polyketide biosynthetic pathways might be rationally reprogrammed by combinatorial manipulation. 聚酮合成酶的酰基转移酶功能域可以特异性地决定所选择酰基辅酶A的种类,决定产物的结构。
- biosynthesis Polyketide synthase 聚酮合酶
- Keywords monascus pigments;polyketide;biosynthesis; 红曲色素;聚酮途径;生物合成;
- Keywords Polyketide;Polyketide synthase;Combinatorial biosynthesis; 聚酮化合物;聚酮合酶;组合生物合成;
- Keywords combinatorial biosynthesis;polyketide;natural product; 组合生物合成;聚酮化合物;天然产物;
- Keywords erythromycin;Escherichia coli expression system;polyketide; 红霉素;大肠杆菌表达系统;聚酮;
- Keywords Monascus;polyketide;Monascorubrin pigment;Monacolin K;Citrinin; 红曲霉;聚酮类化合物;红曲色素;莫那可林K;桔霉素;
- Keywords Sorangium;epothilone;polyketide;KS;horizontal gene transfer; 纤维堆囊菌;埃博霉素;聚酮;酮基合酶;水平转移;
- Molecular screening and distribution of polyketide antibiotics producers from Actinomycetes 产生大环聚酮类天然产物放线菌的分子筛选研究
- Characteristics of Filamentous Fungal Polyketide Synthetase and Their Use in Pathway Engineering 丝状真菌聚酮体合成酶特性及其途径工程
- Keywords Streptomyces avermitilis,avermectins B1,ivermectins,oligomycin,polyketide synthase; 阿维链霉菌;阿维菌素B1;伊维菌素;寡霉素;聚酮合酶;
- Keywords Monascus anka;pigment synthesis;inhibitors of enzymes;polyketide pathway; 红曲霉;色素合成;酶活抑制剂;聚酮途径;
- Keywords polyketide;combinatorial biosynthesis;polyketide synthase;microbial medicine;gene cluster; 聚酮类;组合生物合成;聚酮合酶;微生物药物;基因簇;
- Keywords Antibiotic AGPM;biosynthesis;regulation mechanism;Streptomyces leutogriseus;polyketide;flux analysis; 抗生素AGPM;生物合成;调控机制;藤黄灰链霉菌;聚酮途径;代谢通量分析;
