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- Induction and maintenance of specific immune tolerance is the Holy Grail of organ transplantation. 诱导宿主产生对移植器官的特异性免疫耐受是人们长期追求的目标。
- Antigen specific immune tolerance is induced in a mammalian host by administration of a toleragen in combination with a regimen of immunosuppression. 通过施用耐受原与免疫抑制方案相组合诱导哺乳动物宿主中的抗原特异性免疫耐受。
- After the tolerizing regimen, the host is withdrawn from the suppressive agents, but is able to maintain specific immune tolerance to the immunogenic epitopes present on the toleragen. 在致耐受方案后,将免疫抑制剂从宿主撤离,宿主仍能保持对存在于耐受原上的免疫原性表位的特异性免疫耐受。
- specific immune tolerance 特异性免疫耐受性
- 4 HBsAg loading on DC, which may improve the function of antigen presenting, is a promising and effective way to reverse CHB specific immune tolerance and explore a novel immune therapy for CHB. 4 HBsAg负载DCs可能有望成为改善DCs提呈功能的有效途径,逆转CHB特异性免疫耐受,开发免疫治疗新途径。
- Islet cell transplantation now forms the basis of a prospective multicenter trial under the aegis of the Immune Tolerance Network. 在免疫耐受网络系统的支持下,现在已经开展胰岛移植前瞻性多中心试验研究。
- Objective:To study the mechanism of immune tolerance induce by protal venous injection of donor spleen cells on the dog model of renal transplantation. 目的:利用家犬肾脏移植模型,探讨门静脉注射供体脾细胞诱导免疫耐受的机制。
- Once this immune tolerance break down the immune system would attack its own tissue, resulting in autoimmune diseases. 这种免疫耐受一旦破裂,免疫系统就会攻击自身的组织细胞,导致自体免疫疾病。
- One aspect we called of them the virologic factors that lead to immune tolerance in vivo. 一部分我们称之为体内导致免疫耐受发生的病毒因素。
- With progress of immu nology, the mechanism of immune tolerance is understood better. 随着免疫学的发展,人们对免疫耐受产生机制有了较多的认识。
- Dendritic cells induce efficient and specific immune response against liver cancer in vitro. 肝癌病人树突状细胞诱导高效而特异的抗肝癌免疫。
- Over or under-production of BAFF may disturb immune tolerance, thus triggering certain autoimmune disorders. 其缺陷和过度表达均能引起机体免疫失衡,从而诱发多种自身免疫性疾病。
- Nonspecific barriers to fungal infection must be crossed, however, before specific immune responses to fungi are elicited. 在特异性免疫反应产生之前,起作用的主要是非特异性的屏障结构。
- One aspect we call, called of them the virologic factors that lead to immune tolerance in vivo. 一部分我们称之为体内导致免疫耐受发生的病毒因素。
- Lymphocyte is the immunocyte for specific immune function and acts key role in the process of immune response. 淋巴细胞是具有特异性免疫功能的免疫活性细胞,它们在免疫应答过程中起着核心作用,是构成机体防御系统的重要组成部分。
- To explore the preparation of specific immune RNA on idiotype and further study immunotherapy of tumors. 为进一步研究肿瘤的免疫治疗,探索一种型特异、体专一的肿瘤免疫核糖核酸的制备方法。
- Conclusion: ZPP may induce immune tolerance in BALB / C mouse and the transplanted human lung cancer may be survival in the mouse. 结论: ZPP可引起小鼠对人体肺肿瘤细胞免疫耐受,使移植瘤成活。
- Over expression of indoleamine 2,3-dioxygenase(IDO)is an important mechanism that is responsible for immune tolerance of tumor. 吲哚胺2,3-二加氧酶(idoleamine2,3-dioxy-genase,IDO)的高表达是导致肿瘤免疫耐受的一个重要机制。 诱导IDO的表达具有两种信号传导途径。
- Aplastic anemia, severe combined immunodeficiency and hemoglobin disorders, for example, involve deficiencies of specific immune cells in the blood. 例如再生障碍性贫血、重症联合免疫缺陷和血红蛋白病等血中缺乏特定的免疫细胞。
- Hematopoietic chimerism produces durable and robust immune tolerance to kidney allografts, although incomplete tolerance to donor skin grafting. 造血嵌合能够对肾移植产生持久有力的免疫耐受,但对于皮肤移植无效。