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The voltage gated sodium channel is the major target receptor for DDT and pyrethroids, and is the basis of their cross resistance (knockdown resistance). 电压门控的钠通道是拟除虫菊酯 (Pyrethroid)和滴滴涕 (dichloro diphenyl trichloroethane)的共同靶变点 ,是它们产生交互抗性 (击倒抗性 ,Knockdownresistance)的基础。
Voltage gated sodium channels (VGSC) are responsible for the rising phase of the action potential in the membrane of neurons and most electrically excitable cells. 电压门控钠通道(VGSC)在神经元及大多可兴奋性细胞动作电位的形成和传播过程中扮演着极为重要的角色。
Keywords neurotoxin;voltage gated sodium channel;allosteric modulation;receptor binding site; 神经毒素;电压门控钠通道;变构调制;受体靶点;
Keywords Compound Erjingling polysaccharide;voltage gated sodium channel;Hippocampal neuron; 复方二精灵;海马神经元;电压门控性钠通道;
voltage gated sodium channel 海马神经元
Hyperexcitability of neurons plays a critical role in the generation of neuropathic pain, and appears to be intimately linked to the plasticity of voltage - gated sodium channel subunits. 大量研究表明,神经元的异常兴奋是神经性疼痛产生的主要原因之一,并且这种异常兴奋与钠离子通道亚单位的可塑性有关。
Voltage gated Na + channel(VGSC)is the target of numerous natural neurotoxins. 电压门控钠通道(VGSC)是许多天然生物神经毒素特异作用的靶受体。
Rasmusson RL, Morales MJ, Wang S, et al. Inactivation of voltage gated cardiac K+ channels[J]. Circ Res, 1998,82(7):739 50. 郭洪波;王帅;邹飞.;下丘脑神经元钙激活钾通道的温度效应[J]
Methods: Whole-cell patch clamp technique was used to determine sodium channel cur rent. 方法 :采用全细胞膜片钳技术 ,记录钠通道电流。
Sodium channel of dorsal root ganglion (DRG) plays an important role in the mechanisms of neuropathic pain. 摘要脊髓背根神经节的钠通道与神经性疼痛的形成有密切的关系。
This review focuses on the relationship between the plasticity of voltage-gated sodium channel subunits and neuropathic pain states. 本文就目前研究较多的几种钠通道亚单位的可塑性与神经性疼痛的关系作一综述。
It can activate sodium channel,inrease sodium current.it can inrease liber calcium concentration in the myocardial cell. 实验证明：As可激活钙通道，增加钙通道电流 As增加细胞内游离的钙离子浓度 As可激活钠通道，增加钠电流关键词：龙牙葱木皂苷培养心肌细胞 L-型钙电流钠通道膜片钳正性肌力作用 Aralosides(As)are omni-glycosides extracted from roots;petiols and skins of Aralia (Miq) seem.
These included mutations in the sodium channel gene SCN5A, preiously associated with LQTS and other unstable heart rhythm conditions and sudden death. 这其中包括钠通道基因SCN5A的突变，该基因以前发现与LQTS、其他不稳定心律失常以及猝死相关。
To observe the effect of Garlicin on sodium channel in isolated ventricular cell of rats, to find out the mechanism of antiarrhythmia of Garlicin on the ionic channel level. 目的研究大蒜素对豚鼠心室肌细胞膜快钠通道的影响,探讨大蒜素在离子通道水平的抗心律失常作用机制。
As compared with TTX-R sodium channel, the TTX-S sodium channel was less responsive to Fen exposure, which only led to slowly decay TTX-S sodium tail currents. 氰戊菊酯对TTX-S型钠通道的作用小于TTX-R型，仅表现为对尾电流的关闭有延迟作用。
A man appeared at the castle gate in the guise of a woodcutter. 一个男子打扮成樵夫的模样出现在城堡的门口。
The present study was to investigate the changes of TTX R sodium currents and NaN/SNS2 sodium channel transcripts in DRG neurons in chronic constriction injury (CCI) of sciatic nerve 14 days after surgery. 目的 :观察电压门控钠通道NaN /SNS2在大鼠坐骨神经慢性压迫性损伤 (chronicconstric tioninjury ,CCI) 14天后的变化 ,探讨慢性神经痛的发生机制。
Isolation and Recording of Voltage Gated Potassium Channel of Pulmonary Arterial Smooth Muscle Cells in Rat 大鼠肺动脉平滑肌细胞的分离及电压门控性钾电流的记录方法
Tetrodotoxin is one of the strong marine neural toxins which block sodium channels. 河豚毒素是钠离子通道阻断剂,是一种强海洋神经毒剂。
These anaesthetics block sodium channels and thereby the excitability of all neurons, not just sensory neurons. 这些局麻剂可以阻断钠通道，因此不仅仅阻滞了感觉神经元，也同时阻滞了几乎所有其他神经元的兴奋性。