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- 目的探讨非酒精性脂肪肝小鼠肝脏胰岛素受体底物-2(insulin receptor substrate-2,IRS-2)的表达。Objective To investigate the expression of insulin receptor substrate-2(IRS-2)in the liver of nonalcoholic fatty liver(NAFL)mice.
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- 胰岛素受体底物(Insulin Receptor Substrate，IRS)分子是胰岛素信号通路上的主要调节分子，在维持细胞正常的基础功能上扮演着重要角色。Insulin receptor substrate (IRS) molecules are key mediator in insulin signaling and play a central role in maintaining basic cellular functions.
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- 胰岛素受体底物-1(insulin receptor substrate-1, IRS-1)作为多位点的锚定蛋白，连接受体激酶和信号蛋白质，引起受胰岛素调节的许多细胞内的多种功能的活化。Insulin receptor substrate-1 (IRS-1) acts as a multisite docking protein that binds signal proteins and links the receptor kinase to a number of cellular functions that are regulated by insulin.
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