A novel mutation D421V was identified in AChE from the resistant strain. D421 was positioned at the outer surface of the protein, but this residue could not interact with amino acid residues lining the active site gorge.

• 通过序列比较发现,家蝇残杀威抗性品系的乙酰胆碱酯酶氨基酸序列中有一个新的突变D421V,D421位于蛋白质的外表面,与活性位点谷内氨基酸残基不能形成直接相互作用。