Activation and proliferation of HSC are regulated by several cytokines or signal regulatory proteins in vivo.The surface receptor can activate intracellular signal pathways with cytokines.

• 肝星状细胞在活化增殖过程中受多种细胞因子或蛋白的调控,通过表面受体激活信号转导网络系统,促使肝纤维化的发生发展。