After administration of losartan for 2 weeks and 12 weeks, 24-hour urinary protein excretion (24 hUPE), Scr and Ccr were measured, and renal morphology was observed.

• 分别于2周和12周杀鼠,观察体重、肾重、肾重/体重指数、尿蛋白量(24 h)、Scr、Ccr以及肾组织病理改变;