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- It means that except targeted mutation (TM ), there exits non targeted mutation (NTM), which is the result of genetic instability induced by DNA damaging agents. 即DNA损伤剂除了能直接作用于细胞遗传物质而造成损伤部位的定标性突变(targeted mutation,TM)外,还可能通过诱导某些基因的表达或功能改变导致DNA复制差错,从而在未损伤部位形成非定标性突变(non targeted mutation,NTM)。
- The MPG overexpression HOS cells were significantly more sensitive to the DNA damage agents, including MMS, MNNG, and TMZ, with changes in the IC50 of 6.0, 4.5, and 2.5 fold respectively. MPG过表达HOS显著地提高DNA损伤性化疗药物MMS、MNNG和TMZ的敏感性,其半数抑制浓度(IC50)值分别下降了6·0、4·5和2·5倍。
- DNA damaging agent DNA损伤剂
- Curbing DNA damage might make cancer less likely. 卷曲的DNA损伤导致癌症也很少。
- Catechins may also prevent DNA damage caused by carcinogens. 儿茶酚还可能预防致癌物质引起DNA损伤。
- DNA repair pathways can enable tumor cells to survive DNA damage induced by anti-tumor drugs such as alkylating agents. DNA损伤修复能够使肿瘤细胞耐受化疗药物造成的DNA损伤而存活,因此,调节某种特殊的DNA修复路径可以增强化疗药物的疗效。
- The damaging agents have been grouped according to the type of damage they cause. 为害的因子按其为害的类型进行归类。
- GEN caused DNA damage but not due to oxidant effect. GEN导致细胞DNA断裂,但不是由其氧化效应引起。
- Both UV-A and UV-B irradiation induced DNA damage in mesophylls. 彗星检测结果表明,九里香叶片DNA的损伤程度与UV-B辐射的剂量呈正相关;
- Using such an early donor cell might avoid the risk of accumulated DNA damage. 使用这样的一个早期供体细胞可能避免积聚DNA损伤的风险。
- The DNA damage become more serious as the dose of 1,2,4 - TCB increases. 随着染毒剂量增加,DNA损伤加重。
- DNA damage by mutagens has very serious consequences for DNA replication. 试比较切除修复和光复活机制是如何清除由紫外线诱导形成的嘧啶二聚体的?
- O6-Methylguanine-DNA methyltransferase(MGMT)is an important DNA repair gene in human cells.It plays an important role in resisting cellular DNA damage induced by alkylating agents. O6甲基鸟嘌呤DNA甲基转移酶(MGMT)是细胞中一种重要的DNA损伤修复酶,它在抵御烷化剂所致的细胞突变和死亡中起重要作用。
- Conclusion: Garlic oil can prevent WBC decrease and DNA damage induced by radiation. 结论:大蒜油具有对抗辐射引起的白细胞减少和DNA损伤作用。
- Farinati F,Cardin R,Degan P,et al.Oxidative DNA damage accumulation in gastric carcinogenesis[J].Gut,1998,42(3):351. 厉有名;马先槎;许德兴;等.;幽门螺杆菌与胃窦粘膜肠化生的关系[J]
- Objective To investigate neuronal DNA damage a nd the regulation of Bcl-2after cere bral ischemia and reperfusion. 目的研究脑缺血再灌注(IR)后神经元DNA损伤及Bcl-2的调控作用。
- Objective To study effects of low concentration vinyl chloride(VC) on DNA damage in peripheral lymphocytes. 目的 探索低浓度氯乙烯对外周血淋巴细胞DNA 损伤效应。
- Oliver tail moment was used to evaluate DNA damage of cells from the mice using an IMI comet analysis microsoft. IMI彗星分析软件分析彗星尾距(oliver tail moment,TM)评价细胞DNA损伤的程度。
- He was sent to prison for damaging public property. 他因破坏公共财产被处监禁。
- His resignation is very damaging to the government. 他的辞职给政府带来极大损害。