It is concluded that the method of measuring mannitol and lactulose in the urine using HPLC-PED was a rapid,simple,sensitive one which could be usde to measure intestinal permeability.

• 结论 用带脉冲电化学检测器的高压液相色谱仪测定尿中的甘露醇和乳果糖是一种灵敏度高，特异性强，操作简单、快速的方法，可用于肠通透性的测定。