Ketoprofen was synthesized from anline by amidation, cyclization, benzylation, hydrolysis, deamination and oxidation with an overall yield of 42.5 %.

• 以苯胺为起始原料；经过酰胺化、环合、苄基化、水解、脱胺基、氧化等几步反应；得到产物酮基布洛芬；总收率42.；5%25。