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- The high performance capillary electrophoresis (HPCE) method was established for determining the optical purity of (+) and (-) meptazinol hydrochloride. 建立测定美普他酚对映体的毛细管区带电泳法,代替国外HPLC手性柱的方法,用于检测左旋体和右旋体的光学纯度。
- The routine has been improved for the industrial production.The structure of meptazinol hydrochloride was confirmed by IR, UV, 1HNMR, 13CNMR, MS and DSC. 经元素分析、IR、UV、1HNMR、13CNMR、MS和DSC等分析测试确定盐酸美普他酚结构,HPLC含量测定大于99.;6%25。
- During the preparation of these bivalent candidates, the key step is the demethylation of (+)-meptazinol to give (+)-N-demethyl-meptazinol.Several methods were employed to demethylate meptazinol. 将双配基设计的方法用于美普他酚,以镇痛活性更优的(+)-美普他酚为母体,设计并合成了六个不同长度烃链连接的(+)-去甲美普他酚双配基。
- Meptid 甲氮卓酚, 消痛定, 美他齐诺, 美他西诺[镇痛药]
- meptazinol hydrochloride 盐酸美他齐诺
- Meptazinol 甲氮草酚, 消痛定