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- OBJECTIVE To provide a process for preparing nefiracetam used as an agent for improving cerebral function. 目的合成脑功能改善药奈非西坦并改进合成工艺。
- With 2,6-xylidine as starting material,Nefiracetam,a nootropic was synthesized by N-acylation and N-alkylation.Nefiracetam's structure was confirmed by element analvsis.IR.MS spectra and 1HMNR. 以2,6-甲基苯胺为起始原料,经N-酰化和N-烷基化反应合成了促智药奈非西坦,结构经元素分析、红外、质谱、核磁共振氢谱确证,总收率65%25。
- Keywords nefiracetam;2;6-xylidine;synthesis;alzheimer s dementia; 奈非西坦;2;6-二甲基苯胺;合成;阿尔茨海默氏早老性痴呆;
- Keywords nefiracetam;condensation;synthesis;2;6 xylidine; 奈非西坦;缩合;合成;2;6-二甲基苯胺;
- Keywords nefiracetam nootropic synthesis alazheimer's disease; 奈非西坦;促智药;合成;阿尔茨海默氏病;
- Keywords nefiracetam;related substances;high performance liquid chromatography; 奈非西坦;有关物质;高效液相色谱法;
- Keywords nefiracetam;sodium carbonate;2-chloro-N-（2;6-dimethyl） phenyl acetamide;2-pyrrolidone;sodium ethoxide; 奈非西坦;碳酸钠;2-氯-N-（2;6-二甲基苯基）乙酰胺;2-吡咯烷酮;乙醇钠;
- nefiracetam 奈非西坦
