Objective To investigate the cytotoxicity and proapoptotic activity of topotecan(TPT) on cisplatin-resistant human ovarian cancer cell lines COC1/DDP and its mocular mechanisms.

• 目的探讨拓扑替康(TPT)对人卵巢癌顺铂耐药细胞株COC1/DDP的杀伤和诱导凋亡活性及其作用机制。