Objective To study the role of cycline dependent kinase 4(CDK4) in the malignant transformation of human fetal lung diploid fibroblast cell(2BS) induced by silica.

• 目的 探讨细胞周期蛋白依赖激酶K4(CDK4)在石英致人胚肺成纤维细胞(2BS)恶性转化过程中所起的作用,为石英致癌机制提供理论依据。