Serious insecticide resistance (IR) of the house fly (Musca domestica), caused by consecutive DDT abuse, was firstly found in Switzerland in 1946.

• 1946年在瑞士因连续使用DDT防治家蝇而产生严重的抗药性后，导致防治失效，引起了人们对昆虫抗药性的重视。