Then,the regioselective ortho lithiation of alkyloxypyridine bromide was further performed to produce the diphenylphosphine alkyloxypyridine bromide derivatives(3a,3b and 6a).

• 以氯代吡啶为原料,经烷氧基取代,选择性单溴代,合成了系列烷氧基溴代吡啶,最后利用锂化反应的区域选择性,制备了二苯基膦烷氧基溴代吡啶;