This study identifies the major deubiquitinase for histone H2A and demonstrates that H2A deubiquitination is critically involved in cell cycle progression and gene expression.

• 研究鉴定了组蛋白H2A主要去泛素化酶并证明H2A去泛素化在参与细胞周期进程和基因表达中起着重要作用。