Three insulin A-chain analogues with substitution by basic amino acia residues at A8-10 positions inside the intra-disulfide bonds were synthesized by the solid phase methods with Fmoc protection strategy.

• 本文报道了用Fmoc固相法合成3种胰岛素A链小环（A8－10）被不同碱性氨基酸取代的A链类似物，并分别与天然胰岛素B链重组成相应胰岛素类似物；