With improred wakayama method, the animal experimental models of SAP were manufactured by infusing four activators (sodium desoxycholate, bile, blood bile salt and chymotrypsin) into the major pancreatic duct of dog.

• 采用4种激活剂(去氧胆酸钠、牛胆盐、糜蛋白酶、胆汁加狗血)改良的Wakayama方法经杂交狗主胰管注入；制作重症急性胰腺炎实验动物模型.