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OBJECTIVE To improve the synthetic procedure of cilnidipine. 目的改进二氢吡啶类钙拮抗剂西尼地平的合成工艺。
Cilnidipine is a new dihydropyridine (DHP) type of calcium channel antagonist. 西尼地平是新型的二氢吡啶类(DHP)钙通道拮抗剂，临床上用于治疗高血压和心绞痛；
METHODS Cilnidipine was synthesized from cinnamyl alcohol by esterification,aminization and condensation-cyclization. 方法以肉桂醇为原料,经酯化、氨化和缩合-环合而得。
ABSTRACT Objective: To study the effect of the intestinal absorption kinetics of cilnidipine on doxofylline in rats. 摘要目的：考察西尼地平对多索茶碱大鼠在体肠吸收的影响。
Conclusion: Cilnidipine disturbed the intestinal absorption of doxofylline in rats. 结论：西尼地平干扰了多索茶碱在小肠部位的吸收。
In this paper,synthesis of cilnidipine and its pharmacological action were introduced and reviewed. 作者介绍了国内外近年来西尼地平的合成及药理作用研究进展情况。
Cilnidipine was a novel dihydropyridin calcium antagonist including type L and Type N calcium channel. 摘要西尼地平是兼具有L型和N型钙通道阻滞作用的新型钙拮抗剂。
The paper discusses the research process of synthesizing route, method and medicine function for 1,4-dihydropyridine(such as: cilnidipine, niludipine). 讨论了1;4-二氢吡啶类钙拮抗剂(如:西尼地平、尼鲁地平)的合成路线、方法和药理作用方面的研究进展.
After 8 weeks treatment with cilnidipine,EDT and IVRT were significantly decreased and E,E/A,Ea and Ea/Aa were significantly increased without changes in A,Sa and Aa. 治疗后E波减速时间(EDT)较治疗前降低(P<0.;05);治疗后E、E/A、Ea均较治疗前升高(P<0
AIM A HPLC method for the determination of cilnidipine and its major metabolite was developed and the kinetics of its metabolism in human liver microsomes was studied. 目的建立人肝微粒体中西尼地平及其脱氢代谢物的HPLC测定法,并用本法研究西尼地平在人肝微粒体中代谢的动力学。
CONCLUSION: Similar with domestic cilnidipine tablet,domestic cilnidipine capsule is effective and safe in treatment of mild to moderate essential hypertension. 结论:国产西尼地平胶囊与国产西尼地平片相似,治疗轻中度原发性高血压具有明确的降压疗效与良好的安全性。
Cilnidipine can effectively inhibit reflex overactivity of SNS besides its hypotensive action.Together with its other pharmacological effects, cilnidipine might protect target organs form lesion. 它不仅可以有效地降低血压，还可以有效预防反射性交感神经兴奋，和该药的其他有益作用一起，对减轻高血压的靶器官损害有一定作用。
Cilnidipine can effectively inhibit reflex overactivity of SNS besides its hypotensive action.Together with its other pharmacological effects,cilnidipine might protect target organs from lesion. 它不仅可以有效地降低血压,还可以有效预防反射性交感神经兴奋,和该药的其他有益作用一起,对减轻高血压的靶器官损害有一定作用。
Different technotogy of Cilnidipine Tablets was compared in this study,and selected the best technotogy by observing appearance,hardness,the time of disintegrating and dissolution rate. 通过对西尼地平片不同处方工艺的比较研究,以片面外观、硬度、崩解时间及溶出度作为主要考察指标,确定了其最佳工艺。
Keywords Cinildipine;Human serum albumin;Fluorescence spectrophotometry; 西尼地平;人血清白蛋白;荧光光谱法;
Keywords synthesizing of medicines;medicine function;cilnidipine;niludipine; 药物物合成;药理作用;西尼地平;尼鲁地平;
Efficacy and safety of a novel calcium antagonist cilnidipine in treatment of essential hypertension 国产西尼地平治疗轻中度高血压有效性及安全性研究
Identification for the Hydrogen and Carbon Spectra of Cilnidipine by Nuclear Magnetic Resonance 西尼地平核磁共振碳谱氢谱的谱峰归属
Keywords patent;cardiovascular agents;metoprolol;cilnidipine;irbesartan;administrative protection of pharmaceuticals; 专利;心血管药物;美托洛尔;西尼地坦;药品行政保护;
Keywords cilnidipine;N type Ca 2+ channel antagonist;sympatho inhibitory activity; 西尼地平;N-型钙通道阻滞剂;交感神经抑制活性;