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- Methods The loss of heterozygosity (LOH)of YNZ22, APC, MCC and DCC genes was examined by PCR RFLP technique in 60 IM cases. 方法 应用PCR?RFLP法检测了60 例肠化生组织中YNZ22、APC 、MCC、DCC基因杂合性缺失现象。
- Objective To evaluate the loss of heterozygosity (LOH) and microsatellite instability (MSI) in the early diagnosis of bladder cancer. 目的探讨染色体微卫星不稳定性(MSI)及杂合性丢失(LOH)在膀胱癌早期诊断中的意义。
- Thirteen (2/15) percent of acute leukemia patients had loss of heterozygosity (LOH);the rate was higher than that in other leukemia types. 15例急性白血病中2例有LOH，比其他白血病发生率高。
- It was found that loss of heterozygosity(LOH) at MCC,LOH of DCC and LOH of YNZ22 loci were detected in 34.8%,36.0%and 43.3% of informative cases,respectively. 大肠癌MCC基因LOH率为34.;8%25； DCC基因为36
- Objective: To explore the role of the loss of heterozygosity (LOH) of DCC gene in the occurrence and development of primary hepatocellular cancer (HCC). 目的：了解结肠癌缺失基因（DCC基因）在原发肝癌发生发展中的作用。
- Objective: To investigate the relationship between the loss of heterozygosity(LOH) of MCC, DCC or YNZ22 loci and the development and progression of colorectal carcinoma. 目的：研究MCC、DCC基因和YNZ22位点杂合性丢失（LOH）与大肠癌发生发展的关系。
- Objective To study the relationship between the loss of heterozygosity (LOH) at APC and MCC genetic loci and the incidence and development of esophageal carcinoma. 目的研究APC/MCC基因杂合性缺失(LOH)与食管癌发生发展的关系。
- Objective: To detect the status of loss of heterozygosity (LOH) on chromosome 8 in prostate carcinoma and high grade prostatic intraepithelial neoplasia (PIN). 目的:分析原发性前列腺癌及高级别前列腺上皮内肿瘤(PIN)8号染色体等位基因杂合性缺失(LOH)并探讨其意义。
- Relative survival(RS%),relative suspension growth(RSG%),mutation frequency at tk locus and percentages of slow growth mutant(SC%) were detected and loss of heterozygosity(LOH) of mutants were analyzed. 检测细胞相对存活率(RS%25)、相对悬浮增长率(RTG%25)、tk位点突变频率(M F)和缓慢生长集落的百分比(SC%25),同时对突变集落tk位点杂合性丢失(LOH)进行分析。
- Objective To explore the relationship of the telomere length to microsatellite instability (MSI) and to loss of heterozygosity (LOH) of APC, MCC and DCC genes in gastric carcinomas. 目的 探讨端粒长度与微卫星不稳定 (MSI)和APC MCC及DCC基因杂合丢失 (LOH)的关系。
- Methods 20 loci on chromosome 9 were examined to detect loss of heterozygosity(LOH) in 21 cases of glioblastoma by PCR based microsatellite polymorphism analy-ses, in which fluorescence-labeled primers and Perkin Elmer 377 DNA Sequencer were applied. 方法 应用聚合酶链反应（PCR）方法，采用荧光标记引物和377型DNA序列自动分析仪，分析21例 GBM 9号染色体上 20个微卫星多态性标记的LOH。
- Study on loss of heterozygosity of DCC in primary gastric carcinoma. 原发性胃癌中DCC抑癌基因杂合性丢失的研究
- A study on the loss of heterozygosity at 17p13.3 and abnormal expression of p53 protein in gastric carcinoma. 胃癌组织17p13.;3杂合性丢失及p53蛋白异常表达的研究
- Loss of heterozygosity at different chromosomes in pa-tients with breast cancer. 乳腺癌病人不同染色体位点上杂合缺失的研究
- In addition, 36.4% (8/22) of prostatic tumor tissues had loss of heterozygosity of GNMT gene. 此外，摄护腺癌组织GNMT基因有36.;4%25 (8/22)异合性丧失的情形；
- In conclusion, the Lanyu pig is a unique breed without gene introgression from exotic pig breeds, but it had sustained loss of heterozygosity. 综合以上之结果，推论保种兰屿猪与以上6个台湾外来猪种间发生基因交流之可能性低为一独特之族群，但此族群可能因近亲配种致其基因多型性流失。
- METHODS: Twenty-three fresh resection samples of colorectal carcinomas were studied by the polymerase chain reaction (PCR) to detect the loss of heterozygosity of DCC. 方法:采用聚合酶链反应方法(polymerasechainreaction,PCR)对23例结直肠癌组织新鲜标本DCC基因杂合性缺失(lossofheterozygosity,LOH)进行研究。
- Microsatellite analysis showed that both loss of heterozygosity and microsatellite instability of FHIT gene existed in laryngeal carcinoma and the former was more common. 微卫星多态分析表明，FHIT基因在喉癌中既存在杂合性丢失，又存在微卫星不稳定现象，但以前者为主。
- Associations between compartment-specific TP53 status, loss of heterozygosity or allelic imbalance, and clinical and pathological characteristics were computed. 协会之间的隔间具体tp53地位，杂合性缺失或等位基因不平衡现象更加严重，临床及病理特征的计算机。
- Cong WM,Wu MC.Features of microsatellite instability and loss of heterozygosity of intrahepatic cholangiocarcinoma[J].Zhonghua Zhongliu Zazhi(Chin J Oncol),2002,24(2):141. [24]丛文铭;吴孟超.;肝内胆管癌的微卫星不稳定性和杂合性缺失特点[J]
