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- The androgen receptor(AR)belongs to the steroid receptor family,which is a part of the large nuclear receptor superfamily. 雄激素受体(AR)属于核受体超家族中的类固醇受体。
- Peroxisome proliferator-activated receptor(PPAR) is a transcription factor,belongs to the nuclear receptors family,plays a critical role in the pathophysiology of cardiac hypertrophy. 过氧化物酶体增殖激活受体(PPAR)是甾体激素受体超家族的新成员,能被脂肪酸以及外源性过氧化物酶体增殖剂激活,而调控参与脂类代谢的某些酶的基因表达。
- Abstract:The peroxisome proliferator activated receptor (PPAR) belongs to a large family of nuclear receptors. PPAR基因是近年发现的与脂类代谢有重要关联的核受体基因。
- Probably the new nuclear receptor ligands such as FXR ligand will be the next compound. 新的核受体配体很可能成为下一代化合物,如FXR配体。
- MC5R gene is one of the Melanocortin receptor family, and is ralated to animal obsity. 摘要MC5R基因是黑素皮质素受体家族的一员,与动物肥胖相关。
- Objective To determine the ETO interaction domain of nuclear receptor co repressor (N CoR) for abolishing the biological function of AML1 ETO. 目的 为消除急性髓系白血病标志基因AML1/ETO的活性 ,确定核受体辅助抑制因子(nuclearreceptorco repressor,N CoR)与ETO基因相互作用的活性部位。
- Androgen receptor belongs to the nuclear receptor superfamily and is a ligand-dependent transcription regulator, which can be activated by androgen. 雄激素受体属于核受体超家族,为配体依赖性基因转录因子,与雄激素结合后被激活。
- The Nuclear Receptor Coactivator AIB1 Mediates Insulin-like Growth Factor I-induced Phenotypic Changes in Human Breast Cancer Cells. 主要学术内容和意义:核受体辅激活子AIB1(乳腺癌中扩增)在人类乳腺癌细胞中通过雌激素信号过表达。
- GnRH-R belongs to the G protein coupled receptor family, and it is consisted of a polypeptide chain containing 7 transmembrane domains. The GnRH-R encodes 327/328 amino acids. 研究结果提示,GnRH-R属于G蛋白偶联受体家族,由包含7次跨膜结构域的单一多肽链构成,编码327或328位氨基酸。
- This article reviewed the advance in study on nuclear receptor mediating cell proliferation differentiation and apoptosis. 现就核受体介导细胞增殖、分化与凋亡的作用机制研究进展做一综述。
- The discovery that the HR protein is a nuclear receptor corepressor indicated that HR function in hair cycling is by regulating gene expression. HR蛋白是细胞核受体辅阻遏物的发现证明HR蛋白是通过在毛发周期中调节基因表达来发挥作用的。
- In this article, we reviewed the research advancement in the signal transduction pathway of nuclear receptor and membrane receptor during the activation of hepatic stellate cells. 本文就肝星状细胞激活过程中一些重要的膜受体、核受体信号转导途径及其研究进展作一综述。
- Recent work linking these pathways in epithelial stem cell differentiation has come from studies analyzing the in vivo function of the nuclear receptor corepressor, Hairless (HR). 近来的有关表皮干细胞分化的途径的工作基于分析细胞核受体辅阻遏物HR的体内作用的研究。
- Abstract :Nuclear receptor (NR) is a ligand-dependent transcriptional factor which plays an important role in the metabolism of xenobiotics and endobiotics. 摘 要 :核受体是一种配体依赖性转录因子,在外源性物质和内源性物质的代谢中具有重要作用。
- Until now, many nuclear receptor coactivators were cloned including RIP 140, CBP/P300, SRC/pl60, CARM-1, TRAP/DRIP, and the newly discovered SRA (a small RNA molecular serving as a coactivator). 迄今已分离鉴定出大量的核受体辅活化子,如RIP140、CBP/P300、SRC/p160家族、CARM-1、TRAP/DRIP等,包括最近发现的SRA(一种有辅活化子功能的RNA)。
- Previously we found that DHF patients’ sera contain higher titer against TNF receptor families, including TRAIL-R1 (DR4). 先前我们的研究中发现DHF病人血清中能交互作用到肿瘤坏死因子群中的DR4。
- Estrogen receptor (ER), an important transcription factor belonging to the nuclear receptor superfamily, plays a key role in reproductive, cardiovascular and central nervous systems and bone tissue. 摘要雌激素受体属于核受体超家族成员,是一类重要的核转录因子,它在生殖系统、骨组织、心血管和中枢神经系统中发挥著重要的生理作用,是治疗骨质疏松和乳腺癌的重要药物作用靶标。
- Objective To investigate the localization and expression pattern of nuclear receptor NR4A1 protein in follicle and corpus luteum cells at different estrous stages in cycling female SD rat. 目的:通过研究核受体NR4A1蛋白在正常雌性SD大鼠不同卵巢功能周期的不同发育阶段卵泡及黄体细胞中的表达,推测其在卵泡发育中的生物学作用。
- She only unbends in the family circle. 她只在家庭环境里才不拘束。
- Estrogen receptor(ER),an important transcription factor belonging to the nuclear receptor superfamily,plays a key role in reproductive,cardiovascular and central nervous systems and bone tissue. 雌激素受体属于核受体超家族成员,是一类重要的核转录因子,它在生殖系统、骨组织、心血管和中枢神经系统中发挥着重要的生理作用,是治疗骨质疏松和乳腺癌的重要药物作用靶标。