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- thymidine kinase deficient 缺乏胸(腺嘧啶脱氧核)苷激酶
- Objective To evaluate the bystander effect in the retrovirus vector the herpes simplex virus thymidine kinase gene Ganciclovir system (RV HSV tk GCV). 目的 研究反转录病毒载体 (RV) -单纯疱疹病毒胸苷激酶基因 (HSV tK) -环丙氧苷 (GCV)系统中的旁观者效应。
- ILTV has thymidine kinase ( TK ) gene which has been shown is associated with its virulence and reactivation from the latent state. TK ) 病毒毒力基因，此基因与病毒毒力及病毒于潜伏期再活化的能力有关。
- Objective To study the mechanism of bystander effect in herpes simplex virus thymidine kinase(HSV TK)/Ganciclovir(GCV) mediated gene therapy. 目的 探讨用单纯疱疹病毒胸腺嘧啶核苷激酶（HSV?TK）/丙氧鸟苷（GCV） 系统进行基因治疗时发生的旁观者效应机制。
- Objective To evaluate the efficacy of gene therapy with herpes simplex virus thymidine kinase (HSV - tk) gene transfer followed by ganciclovir (GCV) therapy in lung adenocarcinoma. 目的探讨单纯疱疹病毒胸苷激酶(HSV-tk)基因转染联合抗病毒药物更昔洛韦(GCV)对人肺腺癌细胞系的杀伤作用。
- Objective To investigate the augmentation effect and mechanism of all trans retinoic acid(ATRA)on the bystander effect of herpes simplex virus thymidine kinase (HSV TK)/ganciclovir(GCV) system in the treatment of tongue carcinoma cell line. 目的 探讨全反式维甲酸 (all transretinoicacid ,ATRA)对单纯疱疹病毒胸苷酸激酶(herpessimplexvirusthymidinekinase ,HSV TK) /丙氧鸟苷 (ganciclovir,GCV)系统治疗舌鳞癌旁观者效应的增强作用及机制。
- Objective: To evaluate the efficacy of gene therapy with the herpes simplex virus thymidine kinase (HSV TK) gene transference followed by ganciclovir (GCV) therapy in ovarian cancer. 目的：探讨单纯疱疹病毒胸苷激酶（HSV－TK）基因转染联合抗病毒药物羟基无环鸟苷（GCV）对人卵巢癌细胞系的杀伤效应。
- Objective:To evaluate the treatment effect of retrovirus mediated herpes simplex virus thymidine kinase(HSV 1 tk) gene transference followed by administration of ganciclovir(GCV) and acyclovir(ACV) on ovarian epithelial cancer cells. 目的 :探讨逆转录病毒载体介导的单纯疱疹病毒胸苷激酶 (HSV1 tk)基因转染 ,联合抗病毒药物羟甲基无环鸟苷 ( ganciclovir ,GCV)和无环鸟苷 (acyclovir ,ACV )对人卵巢上皮癌 (OEC)细胞系TYK的杀伤作用。
- A thymidine kinase(TK) gene insertion-deleted strain of avian infectious laryngo-tracheitis virus (ILTV), the first genetically engineered vaccine strain candidate for ILT control in our country was developed at our university. 鸡传染性喉气管炎病毒(ILTV)胸苷激酶(TK)基因插入缺失毒株是由我校研制的国内首次构建的ILT基因工程疫苗候选株。
- A transfering vector was constructed by inserted NDV F gene and IBDV VPO gene, under the control of two synthetic promoters ATI P7. 5X20 which were conjugated at opposite direction inserted within the thymidine kinase (TK) gene of FPV 282E4 strain. 将NDV F基因和IBDV VPO基因分别置于人工合成的复合启动子ATI·p7.;5×20的下游，将两个表达单元以复合启动子反向方式连接，插入TK基因中，得到两个复合启动子分别调控两个不同基因的重组转移质粒pVPO-2ATI·p7
- TK-gene system (retrovirus transfer of the herpes simplex virus thymidine kinase gene) is one of the much more mature plans. We have succeeded in transmitting herpes TK gene into human pancreatic cancer cells, named SW1990 by retrovirus. 由缺陷型逆转录病毒介导的TK基因系统（RV－HSV－TK）是众多肿瘤生物治疗方法中一个技术较为成熟的方案，本实验采用该系统在体外成功地转染了人胰腺癌细胞株SW1990并能够稳定传代培养，转染了TK基因的SW1990细胞（SW±K），其生长曲线与未转染的SW1990细胞无差异。
- Methods Recombinant expression vectors containing CD (cytosine deaminase)and/or TK(thymidine kinase) gene under CMV promoter were constructed successfully. The vectors were transfected to GLC-82 tumor cell lines by use of lipofectamine. 方法 分别构建了以 CMV为启动子 ;含单纯疱疹病毒胸苷激酶（ HSV-TK）和 /或大肠杆菌胞嘧啶脱氨酶（ Ecoli.;CD）单、双自杀基因的真核表达载体。
- Intact BHRF1, DNase, thymidine kinase (TK) and nuclear antigen?1 gene fragments of EBV were amplified using PCR technique with DNAs from B??95?8? and SUNE?1 cell lines as template. PCR从SUNE?1细胞DNA中扩增出EB病毒的4种（BHRF1、DNA酶、胸苷激酶及核抗原?1）全基因片段；
- Poorly differentiated nasopharyngeal carcinoma (SUNE 1) cell line was cultured with Epstein Barr virus (EBV) BHRF1, DNase, thymidine kinase (TK) and nuclear antigen 1 (EBNA1) antisense oligodeoxynucleotide (ASO) for 48 h respectively. 用不同浓度的EB病毒 4种 (BHRF1、DNA酶、核抗原 1及胸苷激酶 )反义寡核苷酸片段 ,(antisenseoligodeoxynucleotide ,ASO)分别与含 10%25胎牛血清或不含胎牛血清的人低分化鼻咽癌细胞株 (SUNE 1)共同培养 4 8h。
- Two plasmids containing a single copy of hepatitis B virus (HBV) genome (ayw or adw) have been introduced into mouse Ltk-cells by calcium precepitation and cotransformation with cloned herpes simplex virus thymidine kinase (tk) gene. 用共转化技术分别将两种亚型的单拷贝HBV-DNA重组质粒与HSV-tk基因一起导入Ltk细胞获得成功。
- Objective Preparition of monoclone antibody to human thymidine kinase(hTK). 目的制备人胸苷激酶单克隆抗体。
- Herpes simplex virus thymidine kinase (HSV- TK) 单纯疱疹病毒胸苷激酶
- We have identified conserved domains of the thymidine kinase proteins of the alpha herpes viruses:-R*Y*DG**G*GK*T-and-FDRHP*A***C*P*AR-. 在氨基酸序列中发现有疱疹病毒TK基因的保守序列R*Y*DG**G*GK*T-和-FDRHP*A***C*P*AR-。
- Next, patients are given an antiviral drug, Ganciclovir, which the thymidine kinase then converts into a substance that destroys all dividing cells. 接下来，将抗病毒药物Ganciclovir注射到病人体内，Ganciclovir能将胸苷激酶转化为一种能杀死所有分裂细胞的物质。
- Objective: To observe the killing effect of Herpes Simplex Virus thymidine kinase gene/Acyclovir system(HSV tk/ACV) on human hepatocarcinoma cells in vitro. 目的 :观察单纯疱疹病毒胸苷激酶基因 (HSV - tk基因 ,自杀基因 )与阿昔洛韦 (ACV)系统对人肝癌细胞的体外杀伤效果。
