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- Objective:To establish a low-cost synthetic route of thymopentin. 目的:研究免疫增强剂胸腺五肽的合成路线,以降低合成成本。
- Objective to observe the curative effect of cisplatin on malignant pleural effusion combined with thymopentin at patients. 摘要目的观察顺铂联合胸腺五肽治疗恶性胸腔积液的疗效。
- Thymopentin (TP5) has been recently evaluated as an immunotherapeutic agent for the treatment of cancer. 胸腺五肽(TP5)近来被认为是肿瘤治疗的免疫治疗剂。
- OBJECTIVE To investigate the preparation of thymopentin loaded oral modified-chitosan nanoparticles(Tp5-TMC-NP). 目的探讨以三甲基壳聚糖为材料制备胸腺五肽纳米粒的制备条件。
- Evaluation of clinical efficacy and tolerability of intravenous high dose thymopentin in advanced melanoma patients. 大剂量静脉注射TP5在进展性黑色素瘤患者中的临床应用及...
- OBJECTIVE To prepare thymopentin microspheres and investigate the drug release in vitro. 目的制备胸腺五肽微球并对其体外释放进行考察。
- Conclusion D-amino acids substituted peptides of thymopentin had stronger immunological activity than thymopentin. 结论D-氨基酸置换的胸腺五肽类似物对T淋巴细胞的免疫调节作用比胸腺五肽作用更强。
- Purpose To synthesize a peptide library of thymopentin with D-amino acids substituted, and to determine its effect of lymphocytic proliferation. 摘要目的合成胸腺五肽D型氨基酸取代肽库,并测定对T淋巴细胞的免疫活性。
- Teabag method was used to synthesize the peptide library of thymopentin with D-amino acids substituted by solid phase peptide synthesis (SPPS). 利用组合化学技术,采用简便的茶袋法固相合成制备胸腺五肽D型氨基酸取代类似物肽库,共合成32条肽。
- There are some surely therapeutic effect for cisplatin combination with thymopentin on patients with malignant pleural effusion, and it can improve their quality of life (QOL). 顺铂联合胸腺五肽治疗恶性胸腔积液有确切疗效,明显提高化疗药物敏感性,进而提高患者的生活质量。
- Cisplatin and thymopentin were injected into thoracic cavity in trial group patients after all pleural fluid released out, but only cisplatin was injected in control group. 观察组患者放尽胸水后经胸腔内注入顺铂加胸腺五肽进行治疗,对照组患者放尽胸水后经胸腔内注入顺铂进行治疗。
- Therefore, there's in need we should combine immune modulator, and anti-virus like polysaccharide, thymopentin or something, must combine anti-virus drugs. 因此,我们可以合并免疫调节药物,例如云芝多糖,胸腺肽等,然后和抗病毒药物一起使用。
- The pentapeptide Thymopentin (TP5) is the fragment of thymopoietin II(32-36) with basic sequence H-Arg-Lys-Asp-Val-Tyr-OH. It has the same biological activity as the thymopoietin II, which has the double-direction immunities to our bodies. 以H-Arg-Lys-Asp-Val-Tyr-OH 为序列的胸腺五肽(TP5)是胸腺生成素II(Thymopoietin II)中第32~36 位的氨基酸残基片段,它保留了胸腺生成素II原有的生物活性,对机体的免疫系统具有双向调节作用,现已作为药物投放市场。
- HATU as the coupling reagent; TFA, p-methyl phenol, EDT and H2O (97:0.25:0.25:2.5) as the cleavage condition, the yield of thymopentin was 79.68% and the purity was 80.36% under 2 equiv. 反应结果胸腺五肽纯度达80.;36%25;收率达79
- Teabag method was used to synthesize the peptide library of thymopentin with D-amino acids substituted by solid phase peptide synthesis (SPPS).Thirty-two peptides were synthesized. 利用组合化学技术,采用简便的茶袋法固相合成制备胸腺五肽D型氨基酸取代类似物肽库,共合成32条肽。
- Conclusions There are some surely therapeutic effect for cisplatin combination with thymopentin on patients with malignant pleural effusion, and it can improve their quality of life (QOL). 结论顺铂联合胸腺五肽治疗恶性胸腔积液有确切疗效,明显提高化疗药物敏感性,进而提高患者的生活质量。
- thymopentin continuous release microspheres 胸腺五肽长效微球
- Keywords microwave;cleavage;thymopentin;peptide resin; 微波;切割;胸腺五肽;肽树脂;
- SEPARATION OF SOLID PHASE SYNTHESIS THYMOPENTIN USING ION-EXCHANGE METHOD 离子交换法分离固相合成胸腺五肽