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The study investigates the 'bystander effect'. 这项研究调查了“旁观者效应”。
Study on the bystander effect of the Ad/HSV1-tk/GCV, ACV system on ovarian epithelial cancer cells. 腺病毒/HSV_1-tk/GCV、ACV系统对卵巢上皮癌细胞旁观者效应的研究
HSV - tk/ACV system showed strong cytotoxic effect, which suggested to has a strong bystander effect in vivo. 在体内HSV-tk/ACV系统具有强的细胞毒作用,提示存在着强的旁观者效应。
Mixed cells containing only 10%of transduced cells showed 50.7%reduction of proliferation (bystander effect). 混合细胞中含10%25的转化细胞时，生长抑制率已达50.;7%25；
Objective To study the role of bystander effect in the cytocidal activity of TK/GCV against tumor cells. 目的研究旁观者效应在TK/GCV系统杀灭肿瘤细胞中的作用。
When Ganciclovir was added, an increased cell killing, or the bystander effect was observed for EBV positive cells. 而添加GCV后能进一步提高rAdv-OCpZebra对EBV阳性细胞的杀伤效率，观察到了一定的旁观者效应。
Objective To evaluate the bystander effect in the retrovirus vector the herpes simplex virus thymidine kinase gene Ganciclovir system (RV HSV tk GCV). 目的研究反转录病毒载体 (RV) -单纯疱疹病毒胸苷激酶基因 (HSV tK) -环丙氧苷 (GCV)系统中的旁观者效应。
The number of escalating gestures did not rise significantly as the size of the group increased, contrary to what the bystander effect would predict. 跟所谓的“旁观者效应”刚好相反，当介入其中的人越来越多的时候，“升级姿态”的数量并没有显著增多。
Objective To study the mechanism of bystander effect in herpes simplex virus thymidine kinase(HSV TK)/Ganciclovir(GCV) mediated gene therapy. 目的探讨用单纯疱疹病毒胸腺嘧啶核苷激酶（HSV?TK）/丙氧鸟苷（GCV）系统进行基因治疗时发生的旁观者效应机制。
The mechanism is not clear, maybe relate to bystander effect, free radicles, DNA repair-deficiency, telomere function disorder and gene partial or total deletion. 基因组不稳定性的机制目前还不甚清楚,可能与旁效应、自由基、DNA修复缺陷、端粒功能失调以及基因大片段缺失等有关。
Freeman S M,Abboud C N,Whartenby K A,et al.The "bystander effect":Tumor regression when a fraction of the tumor mass is genetically modified[J].Cancer Res,1993,53(21):5274. 杜标炎;谭宇蕙;吴应雅;等.;自杀基因联合中医药疗法治疗肿瘤的设想[J]
Conclusion Bystander effect plays an important role in the cytocidal activity of TK/GCV against tumor cells, and is quite relative to intercellular contact. 结论旁观者效应在TK/GCV系统杀灭瘤细胞中起重要作用，且这一效应与细胞间密切接触有关。
Objective To investigate the augmentation effect and mechanism of all trans retinoic acid(ATRA)on the bystander effect of herpes simplex virus thymidine kinase (HSV TK)/ganciclovir(GCV) system in the treatment of tongue carcinoma cell line. 目的探讨全反式维甲酸 (all transretinoicacid ,ATRA)对单纯疱疹病毒胸苷酸激酶(herpessimplexvirusthymidinekinase ,HSV TK) /丙氧鸟苷 (ganciclovir,GCV)系统治疗舌鳞癌旁观者效应的增强作用及机制。
Objective To investigate the killing effect of herpes simplex virus thymidine kinase/gancyclovir (HSV tk/GCV) suicide gene therapy system on retinoblastoma (Rb) cells and the mechanism of bystander effect. 目的研究单纯疱疹病毒胸腺嘧啶核苷激酶 /更昔洛韦 (herpessimplexvirusthymidinekinase /gancyclovir,HSV tk/GCV)自杀基因系统对视网膜母细胞瘤 (retinoblastoma ,Rb)细胞的体外杀伤作用以及旁观者效应发生的机制。
Objective To study the reinforcement of nimodipine to the therapy of acyclovir(ACV)-mediated HSV-TK gene to induce glioma cell to death and the mechanisms of the bystander effect in the procedure. 目的 :探讨尼莫地平增强阿昔洛韦 (ACV)介导的转HyTK基因治疗诱导脑胶质瘤细胞的死亡方式及旁观者效应机制。
The sensitivity of transfected cells to GCV and "bystander effect (BSE)" of HRE-TK/GCV system under normoxia or hypoxia conditions were measured by MTT assay and mixed coculture experiment. 用MTT法和混合共培养实验分别检测转基因细胞在缺氧或不缺氧状态下对GCV的敏感性以及HRE-TK/GCV系统的“旁观者效应”;
To observe if ATRA can enhance the bystander effect of HSV-TK/GCV on BIU-87 cells in vitro. And discuss whether the mechanism is associated to the role of improving the expression of Cx26 and the function of GJIC. 体外观察ATRA是否有提高HSV-TK/GCV对膀胱癌细胞的旁观者杀伤作用,探讨其作用机理是否与提高Cx26的表达及改善膀胱癌细胞细胞间通讯有关。
Bystander effects on unirradiated V79 cells were observed by irradiated conditioned medium (ICM) method and co? cultured with carbon? ion? 用经过碳离子辐照V79细胞的条件培养基(Irradiatedconditionedmedium,简称ICM)和与受照射细胞共同培养两种方法,研究了未受照射细胞的旁观者效应。
In past decade,the researches on genomic instability and bystander effects have become a hotspot of biology and radiobiology. 近10年来,对于基因组不稳定性和旁效应的研究已成为生物学和放射生物学领域的一个热点。
This article makes a brief outline on radiation-induced genomic instability in vivo and in vitro,bystander effects in vivo and in vitro,and the relationship ... 本文就体内、外电离辐射诱发的基因组不稳定性,体内、外旁效应以及二者之间的关系做一简要概述。