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- Results 12(32%) BPH and 1 (6%) normal prostate tissue showed homozygous deletion of MTS1 gene. 结果12例BPH出现MTS1基因缺失，总缺失率为32%25；
- PCR-based procedures were used to identify homozygous deletion of GSTT1 and GSTM1 genes and two polymorphic loci (A1578G, C2293T) in GSTP1 gene. 本研究采用PCR及PCR-RFLP方法对GSTT1，GSTM1的缺失多态性以及GSTP1基因的两个位点A1578G和C2293T的多态性进行了分析。
- SU-DHL-9 had homozygous deletion of p16 gene. Meanwhile, SU-DHL-1 and Daudi cell lines had mutation of the second exon of p16 gene. GAC in codon 30 mutated into AAC. SU-DHL-9有p16基因的纯合缺失,而SU-DHL-1和Daudi细胞系有p16基因的第二外显子的突变,SU-DHL-1的测序结果为密码子30的GAC突变为AAC,密码子35的GCT突变为ACT,密码子40与41之间插入了一个C;
- The frequency of P53,P15 and P16 alteration Was 37.3%,11.9% adn 23.8% respectively and only one case with benign respiratory disease showed P16 homozygous deletion. 肺癌组织中P5 3、P15、P16基因改变频率分别为 37.;3%25、11
- Results Of the 17 cases of primary bladder cancer,2 had homozygous deletion of MTS1 and 2 cases loss of hetrozygosity with the deletion rate of MTS1 being 23.5%(4/17).No mobility shift was found. 结果17例膀胱癌中;2例表现为MTS1基因纯合性缺失;2例表现为杂合性缺失;缺失频率为23.;5%25(4/17);未见异常泳动带。
- Conclusions MTS1 gene was associated with the progression and proliferation in prostatic hyperplasia and homozygous deletion was one of the major inactivation mechanisms of MTS1 gene in BPH. 结论BPH的发病机制可能与MTS1的纯合性缺失有关，未见有突变发生。应对MTS1基因在人BPH中的作用作更深入的研究。
- We also identify 31 recurrent focal events, including 24 amplifications and 7 homozygous deletions. 我们还确定31经常性的联络活动，其中包括24个扩增和7纯合性缺失。
- Objective To study the relationship between the homozygous deletions of DMBT1 gene and clinicopathology in primary lung tumors. 目的探讨DMBT1基因纯合性缺失与原发性肺癌临床病理特征的关系。
- Results: The total homozygous deletions rate of FHIT gene exon 5 and exon 8 were 23.33% and 0% in normal tissues (P=0.01). 结果：胃癌组织中FHIT基因外显子5、8总纯合性缺失率为23.;33%25，正常组织无一例缺失(P=0
- Methods: Frequent homozygous deletions of the CDKN2 gene were detected in 81 cases of brain and spinal cord tumor resection specimens by PCR method. 方法：采用聚合酶链反应(PCR)对81例脑、脊髓肿瘤手术标本中CDKN2基因的丢失情况进行了检测。
- The frequence of intragenic homozygous deletions of DMBT1 of non small cell lung cancer group were higher than that of small cell lung cancer group ( P < 0.05 ). DMBT1基因纯合性缺失率非小细胞肺癌组高于小细胞肺癌组;低、未分化肺癌组高于中、高分化肺癌组;伴有淋巴和/或远处转移组高于不伴转移组;有吸烟史组高于无吸烟史组(P均<0。
- Keywords Hydatidiform mole;CDKN2A gene;Homozygous deletion;Mutation; 葡萄胎;CDKN2A基因;纯合性缺失;突变;
- Homozygous Deletion and Mutation of Exon5 and Exon8 of FHIT Gene in Laryngeal Squamous Cell Carcinoma 喉鳞癌中FHIT基因第5,8外显子纯合性缺失及突变研究
- Analysis of homozygous deletion and point mutation of FHIT gene exon 5 in gastric carcinoma 胃癌中抑癌基因FHIT外显子5纯合性的缺失与突变
- Keywords fragile histidine triad;laryngeal squamous cell carcinoma;homozygous deletion;exon; 脆性组氨酸三联体;喉鳞癌;纯合性缺失;外显子;
- Keywords fragile histidine triad;differentiated thyroid carcinoma;homozygous deletion;genetic mutation; 脆性组氨酸三联体基因;分化型甲状腺癌;纯合性缺失;基因突变;
- Keywords pancreatic cancer;single nucleotide polymorphism array;amplification;homozygous deletion;loss of heterozygosity; 胰腺癌;单核苷酸多态性芯片;扩增;纯合性缺失;杂合性缺失;
- homozygous deletion 同合型缺失, 纯合子缺失
- Homozygous races do not segregate on selfing. 自体受精不能分离纯合的生理小种。
- Subdomain scheduled for deletion! 子域名计划删除！
