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- liver microsomes incubation 肝微粒体孵育
- According to recent materials,Introduce liver microsome incubations in vitro,liver cell incubations in vitro,isolated perfused liver and liver slices,respectively. 对近几年的文献资料进行分析、综合、归纳。
- The metabolism of diphenytriazol was investigated in five kinds of rat liver microsomal incubate pretreated with phenobarbital (PB), dexamethasone (Dex), p-naphthoflavone (BNF), diphenytriazol and control. 方法:l)用CYPIA、CYPZB的两种特征性底物乙氧基异吩恶吟与7一戊氧基异吩恶吟在经不同天数地非三吟处理的鼠肝微粒体中代谢,用荧光仪在激发波长(ex)565nm,发射波长(em)587nln下直接测定代谢物异吩恶吟的生成量。
- Methods In this study, a liquid chromatography-time of flight mass spectrometric method was developed and applied to characterize the metabolites of PAC-1 after incubation with human liver microsomes. 方法 在一定的人肝微粒体浓度中加入药物,温孵后,采用液相色谱-飞行时间质谱法对孵化体系中的代谢产物进行分析。
- IN VITRO METABOLIC STUDIES OF THE NOVEL ANTI-ANXIETIC DRUG AF-5 AND ITS METABOLITES IN HUMAN LIVER MICROSOME INCUBATION SYSTEM 抗焦虑新药AF-5及其代谢物在人肝微粒体体外温孵体系中代谢研究
- Preliminary data indicate that steviol may be activated to a mutagenic metabloite by human liver microsomes. 初步数据显示,甜菊醇可能经人体的肝脏微粒体活化成引致基因突变的代谢物。
- Based on metabolite analysis, several PAC-1 metabolic pathways in human liver microsomes were proposed. 结论 PAC-1在人肝微粒体系中的代谢途径为脱苄基化和羟基化。
- The correlation between peak area of a metabolite and original concentration of Nef in rat liver microsomes solution was significant( r =0.993). 温孵液中代谢产物生成的量与底物Nef的浓度具有良好的相关性(r=0.;993);
- The mean (MEGX+GX)/LDC ratio was 3 2 8. CONCLUSIONThe (MEGX+GX)/LDC ratio can be used to evaluate C YP3A activity of human liver microsomes. 结论 (MEGX +GX) /LDC可用来估算人肝微粒体CYP3A的活性。
- AIM A HPLC method for the determination of cilnidipine and its major metabolite was developed and the kinetics of its metabolism in human liver microsomes was studied. 目的建立人肝微粒体中西尼地平及其脱氢代谢物的HPLC测定法,并用本法研究西尼地平在人肝微粒体中代谢的动力学。
- The proper conditions for testotesrone metabolism in liver microsome system included substrate concentration, incubation time, pH and incubation temperature. 方法:采用超高速离心法制备大鼠肝脏微粒体,建立体外肝脏微粒体混合酶代谢体系。
- CHIRAL RP-HPLC ASSAY FOR PROPAFENONE ENANTIOMERS IN RAT LIVER MICROSOMAL INCUBATES AND ITS APPLICATION IN VITRO METABOLISM 手性衍生化-反相高效液相色谱法测定大鼠肝微粒体中盐酸普罗帕酮对映体及其在代谢研究中的应用
- Keywords nizatidine;rat CYP1A2;liver microsomes; 尼扎替丁;大鼠CYP1A2;肝微粒体;
- Enzyme kinetics of genistein metabolism in rat liver microsomes 染料木黄酮在大鼠肝微粒体代谢的酶动力学
- In this study, we investigated its metabolism by use of rat liver microsome in vitro. 利用大鼠肝微粒体对新农药多噻烷进行体外代谢研究。
- PRN can obviously shorten hypnotic duration of pentobarbital sodium, which suggests that PRN could induce liver microsomal cytochrome P450 in mice. PRN能显著缩短戊巴比妥钠对小鼠的催眠时间 ,提示PRN能诱导小鼠肝微粒体细胞色素P4 5 0活性
- After induced by AFB1 the activity of liver microsomal enzymes in duck has been studied and has been compared with the control groups respectively. 本文对1月龄麻鸭经过黄曲霉毒素诱导后在1月、1年及3年观察其肝微粒体酶(S9)的代谢活性并与各相应对照组进行比较。
- Results and Conclusion : The result s both with and without S9 (rat liver microsomal enzymes) showed that all the samples had no mutagenicity. 结果与结论:经加和不加大鼠肝脏微粒体酶(S9) 两种试验,结果全部受试物均未发现致突变毒性;
- Keywords mitomycin C;cytochrome P450;inducer;inhibitor;liver microsomes; 丝裂霉素C;细胞色素P450;诱导剂;抑制剂;肝微粒体;
- Keywords TM208;Rat liver microsomes;Metabolism;Cytochrome P450 isoform; 大鼠肝微粒体;代谢;细胞色素P450亚型代谢酶;