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- rupatadine fumamte 富马酸卢帕他定
- Objective:To synthesize rupatadine. 目的:合成卢帕他定。
- Results:The total yield of rupatadine was 32.4%. 结果:合成了卢帕他定;总收率32.;4%25。
- Methods:Rupatadine was prepared from loratadine via hydrolysis and alkylation. 方法:以氯雷他定为原料,经水解、烷基化2步反应合成卢帕他定。
- So we infer that rupatadine may have a protective effect on lung inflammatory through its inhibitory effect on synthesis of inflammatory factors. 因此，我们推测对炎症因子释放的抑制可能是卢帕他定产生保护作用的重要原因。
- NEW YORK (Reuters Health) May 21 - Rupatadine is significantly better than placebo for the treatment of chronic idiopathic urticaria, Spanish researchers report in the May issue of Allergy. 纽约路透社健康栏目5月21日报道，研究者发布在过敏症5月刊上的研究表明，卢帕他定治疗慢性特发性荨麻疹显著优于安慰剂。
- Keywords rupatadine;acute lung injury;bronchoalveolar lavage fluid;platelet-activating factor; 卢帕他定;急性肺损伤;支气管肺泡灌洗液;血小板激活因子;
- methylnicotinic acid as a intermediate of rupatadine,was synthesized from 3,5-dimethylpyridine by the reaction of sective oxidation with KMnO4. 以3,5-二甲基吡啶为原料,用高锰酸钾选择性氧化,合成抗过敏性药物卢帕他定中间体5-甲基烟酸。
- rupatadine 卢帕他定<抗凝药; 抗组胺药>
- fumarate rupatadine 富马酸卢帕他定
