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- Vincristine could affect the activity of p38 MAPK in gastric cancer cell SGC7901 and multidrug resistant cell SGC7901/VCR. p38MAPK信号转导途径可能与长春新碱的抗肿瘤活性相关 ,肿瘤细胞内 p38MAPK对长春新碱刺激的反应速度可能与胃癌长春新碱耐药相关
- Human bladder transitional cell cancer BIU 87 cells and multidrug resistant BIU 87/ADM cells were treated with daunorubicin (DNR) combined with JSB 1 and CsA alone or together and with JSB 1 and verapamil(Ver) alone or together. 为了证实抗P?糖蛋白（P?gp）单克隆抗体协同环孢素A（CsA）逆转人膀胱癌耐药细胞亚株的抗药性以及建立能有效地克服MDR的治疗方案，对人膀胱移行细胞癌BIU?87细胞系和BIU?87/ADM耐药细胞亚株经柔红霉素（DNR）与抗P?gp单克隆抗体JSB?1和单独或联合CsA；
- During the development of MDR, epithelial to mesenchymal transition induced by Twist may be related to the enhanced invasion and metastatic potential of multidrug resistant breast cancer cells MCF-7/ADR. 在多药耐药乳腺癌细胞MCF-7/ADR中,其侵袭力增强可能与Twist介导的EMT发生有关。
- Objective To study the effective surgical way for serious relapse multidrug resistant bacillary cavitary pulmonary tuberculosis. 目的寻找通过外科手段治疗内科无法根治的复治耐多药菌阳重症空洞型肺结核的有效途径。
- We summarized the structure,function,distribution,retroconversion,and detect method of the multidrug resistant gene. 现对多药耐药基因的结构、功能、表达、逆转及其检测手段等方面做一综述。
- Multidrug resistant tuberculosis, or MDR-TB, will not get better with antibiotics normally used for tuberculosis. 多药耐受性肺结核，即MDR-TB，用于通常肺结核的抗生素不能使其转好。
- Kruh GD, Cb an A, Myers K et al. Expression complementary DNA transfer establishes map as a multidrug resistance gene[J] ,Cancer Res, 1994,54:1649. 张强;施作霖;陈梓甫.;肾细胞癌对化疗药物的多药耐药机制及其逆转[J]
- Tetrandrine, neferine and dauricine showed obvious potenitiation of vincristine induced apoptosis in the human mammary MCF 7 multidrug resistant cells. 粉防己碱、甲基莲心碱和蝙蝠葛碱均有明显的增强长春新碱诱导人乳腺癌MCF 7多药耐药细胞的凋亡作用
- Obsjective:To observe the reversal effect of Sangen Mixture(SGM) in multidrug resistant(MDR) cell lines K562/ADR and K562/VCR. 目的:研究三根制剂对多药耐药(MDR)细胞株的逆转作用。
- Multidrug resistance (MDR) is the most common cause in the failure of cancer chemotherapy.Drug transporters play an important role in multidrug resistance in cancer. 多药耐药性(MDR)是肿瘤化疗失败的最常见原因,药物转运蛋白在肿瘤多药耐药性中产生了重要的作用。
- A significant impediment to the success of cancer chemotherapy is multidrug resistance (MDR)and this could be attributable to concomitance of multiple intricate mechanisms. 肿瘤多药耐药(MDR)是导致肿瘤化疗失败的主要原因之一,是多种复杂机制共同作用的结果。
- Cao J G,Tang X Q,Zhou H,et al.Reveral of Multidrug Resistance by neferine in adriamycin resistant human breast cancer cell line MCF7/ ADM[J].The Chinese睪erman J Clin Oncol,2004,3(2):9396. 唐小卿;曹建国;冯鉴强.;甲基莲心碱对耐阿霉素人乳腺癌细胞凋亡抗性的影响[J]
- The chemosensitivity of multidrug resistant cell MCF-7Adr and drug sensitive cell MCF-7WTto doxorubicin,vincristine and colchicine was tested by MTT assay. 用MTT方法测定了多药抗药细胞MCF－7Adr及其敏感细胞MCF－7WT对阿霉素、长春新碱、秋水仙碱的化学敏感性。
- On the recent base of research about dietary fiber in all the world, this paper summarize the function of resist cancer and the function of controlling the metabolize of carcinogens. 该文在对近年国内外有关膳食纤维研究文献的研究基础上,总结膳食纤维在抗肿瘤方面机理及对食品中致癌物代谢影响。
- Objective: To investigate the differentiation of multidrug resistant human leukemia cell line K562/ADM induced by cyclic adenosine monophosphate (cyclic AMP, cAMP). 目的:研究环腺苷酸(cyclicadenosinemonophosphate,cAMP)对人白血病多药耐药K562/ADM细胞的诱导分化作用。
- Flow cytometry was used to detect theexpression of HLA-l, HLA-2, B7-l, B7-2 in parent cell lines (COC1 andSKOV3 ) and multidrug resistant cell sublines (COCI/DDP andSKOV3/Adr). 运用流式细胞仪技术检测了各种不同细胞亚株的HLA-1、HLA-2、B7-1、B7-2的表达。 结果：耐药亚株COC1/DDP、SKOV_3/Adr和亲本株COC1、SKOV_3的N-GSLs表达有差异，COC1/DDP、SKOV_3/Adr的CMH表达较COC1、SKOV_3强。
- Methods 104 cases of serious relapse multidrug resistant bacillary cavitary pulmonary tuberculosis were cured by cleaning cavity operation from 1981 to 1998. 方法1981-1998年6月采用空洞清除术治疗复治耐药空洞型肺结核104例。
- Meticillin-resistant staphylococcus aureus (MRSA) is transmissible and multidrug resistant, which made hospital infection rate of it increased yearly and transmitted rapidly. 耐甲氧西林金黄色葡萄球菌(MRSA)具有易传播、多重耐药的特性,使得医院获得性MRSA感染率逐年上升且传播迅速、治疗困难。
- Objective To investigate the restoration of the subcellular distribution of daunorubicin in the P glycoprotein mediated multidrug resistant cell line K562/ADR by quercetin. 目的研究槲皮素处理前后柔红霉素(DNR)在耐药细胞株K562/ADR亚细胞结构的不同分布。
- Objective: To investigate the inhibitory effect of ampelopsin (AMP) combined with adriamycin (ADR) on growth of human leukemia multidrug resistant cell line K562/ADR. 目的：研究蛇葡萄素与阿霉素合用对人白血病多药耐药细胞株K562/ADR增殖的抑制作用及其机制。
