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- Acetylspermidine deacetylase 乙酰亚精胺脱乙酰酶
- High-property chitosan can be produced by chitin deacetylase. 而采用甲壳素脱乙酰酶能制备出性能独特的壳聚糖。
- Histone deacetylase inhibitors had been used to treat cancer and leukemia. 组蛋白去乙酰化酶抑制剂已经越来越多的被用于治疗肿瘤和白血病。
- However, classical research methods which merely focus on single protein are still utilized to study acetyltransferase and deacetylase of Homo sapiens. 目前对于乙酰化酶和去乙酰化酶的研究还基本上是传统的单个蛋白的研究方法。
- In this paper, advances in the application and research of chitin deacetylase in preparation of chitosan are summarized. 本文就甲壳素脱乙酰酶在壳聚糖制备中的应用及研究进展作一综述。
- The pharmacological actions of histone deacetylase inhibitors and their potential clinical uses were reviewed. 综述了组蛋白去乙酰酶抑制剂的药理作用及其临床应用前景。
- Histone deacetylase 3 (HDAC3) has been implicated to play roles in governing cell proliferation. 组蛋白去乙酰化酶3 (HDAC3)在细胞增殖的过程中发挥着重要作用。
- Sensitive assay system for inhibitor screening and kinetic assays of HDAC1 (histone deacetylase 1). 一种用于抑制剂筛选和HDAC1动力学检测的敏感检测系统。
- With intensive study, the mechanism of histone deacetylase inhibitors in leukemia has been paid more and more attention. 随着对组蛋白乙酰化的深入研究,组蛋白去乙酰化酶抑制剂在白血病中的作用机制越来越受到人们的关注。
- Histone deacetylase (HDAC) greatly affects the chromatin topology and gene expression,and HDAC can be a new strategy in human cancer or tumour therapy. 组蛋白去乙酰化酶(HDAC)对染色质分布和基因调节起着重要的作用,也是治疗癌症和其它疾病的新靶点。
- There are two kinds of molecular containing histone deacetylase activity: One is homology with yeast RPD3,and another is not homology with yeast RPD3. 含有组蛋白脱乙酰化酶活性的分子有两类:一类是与酵母RPD3同源的分子,另一类是与RPD3不同源的分子。
- Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase The Sir2 deacetylase modulates organismal life-span in various species. 由SIRT1去乙酰化酶进行的应激依赖的对FOXO转录因子的调节 Sir2去乙酰化酶在不同物种调节寿命。
- Activities of intracellular and intercellular chitin deacetylase were compared produced from several mold strains growing at the end of log phase and stable phase respectively. 比较了几种霉菌(毛霉、根霉、曲霉和青霉)在对数生长末期和稳定期末期的胞内和胞外甲壳素脱乙酰酶的活力。
- Taunton, J., C. A. Hassig, and S. L. Schreiber. "A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p." Science 272, no. 5260 (1996): 408-411. 这两篇文章介绍了组蛋白乙酰转移酶和组蛋白去乙酰化酶的初步分离和与转录的关联。其结果让我们注意到组蛋白修饰是一种很重要的转录调节方式。
- Objective: To observe the synergistic cytotoxicity of histone deacetylase inhibitors TSA or DP with paclitaxel on the NSCLC cell lines, and to elucidate the possible mechanism. 目的:探讨组蛋白去乙酰化酶抑制剂与紫杉醇联合应用,协同抑制NSCLC细胞系的作用和机制。
- Histone deacetylase inhibitors increase the acetylation level of histone as well as some non-histone proteins , and specifically modulate some gene expression. 组蛋白去乙酰酶抑制剂可提高组蛋白的乙酰化水平,并对一些非组蛋白成分产生影响,从而调节某些特定基因的表达。
- FK228 with a special depsipeptide may efficiently pass through the cellular membrane and exert a prominent anti-tumor activity by inhibiting histone deacetylase. FK228具有特殊的缩酯环肽结构,可有效透过细胞膜,通过抑制组蛋白去乙酰酶而显示良好的抗肿瘤活性。
- The multiple-attack mechanism of chitin deacetylase (CDA), the character of enzymatic production ofchitosan, and the cloning and expression of CDA gene are reviewed. 综述了甲壳素脱乙酰酶(CDA)催化甲壳素脱乙酰基的多点进攻作用机理、酶法制备壳聚糖的特性以及克隆表达CDA基因的研究进展。
- Objective To explore the blockade effect of phenylbutyrate (PB),a histone deacetylase inhibitor, on the in vitro biological function of AML1/ETO to reverse its transcription repression and induce Kasumi-1 cells to differentiate and apoptosis. 目的 探讨组蛋白脱乙酰化酶抑制剂苯丁酸钠 (PB)体外阻断AML1 ETO的生物学功能 ,消除AML1 ETO的转录抑制 ,诱导Kasumi 1细胞生长抑制、分化和凋亡作用。
- Objective:To investigate the influence of trichostatin A(TSA),a histone deacetylase(HDAC) inhibitor,on the growth of human bladder cancer cells and on the expression of related genes,and to explore the mechanism involved. 目的:观察组蛋白去乙酰化酶(HDAC)抑制剂曲古霉素A(TSA)对体外培养膀胱癌细胞生长情况及相关基因表达的影响,并探讨其可能的作用机制。