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- autophagic vacuold 自体吞噬泡
- Autophagic lysosome by the evolution from. 均由自噬性溶酶体演化而来。
- To determine whether autophagic activity is altered after TBI, we first examined brain sections by transmission EM. 决定TBI后的自噬活性是否变化,首先在透射电镜下观察脑切片。
- An autophagic activity of vacuoles has been suspected because of the presence in the cell sap of material of cytoplasmic origin. 由于细胞液中存在着来源于细胞质的物质,液泡的自体吞噬活性曾受到怀疑。
- Specimens were observed by optical and dectron microscopy.Results It showed that cells of chorion and decidua had autophagic apoptotic tendency. 结果观察组标本中绒毛膜和蜕膜组织细胞均表现出一种自噬性凋亡倾向。
- Pressure overload stress elicits a robust autophagic response in cardiomyocytes that is maladaptive, contributing to disease progression. 在心肌病中给予超负荷的压力引出强烈的自溶作用是不适当的,会导致疾病进展。
- In this context, load-induced aggregation of intracellular proteins is a proximal event triggering autophagic clearance mechanisms. 本文中,负荷产生的细胞内蛋白质聚集是触发自噬作用清除机制的邻近事件。
- According to its role of waste from different sources, is divided into autophagic lysosome and differences of lysosomal macrophages. 根据其作用废物的来源不同,分为自噬性溶酶体和异噬性溶酶体。
- They exhibit autophagy with a reduction in the number of cell organells, and often a marked increase in the number of autophagic vacuoles. 萎缩细胞发生自噬;其细胞器数量减少,自噬泡常明显增多。
- Autophagy exists but is disrupted because the immaturity of autophagic vacuoles leads to the failure of autophagy circulation. 自噬既有发生又有被破坏, 其破坏的主要原因是自噬小泡的不成熟导致自噬不能有效循环。
- The down-regulation of autophagic activity in some types of tumor-cells is believed to play a critical role of tumorogenesis. 某些肿瘤细胞中自噬活动低下与肿瘤的发生有一定的关系。
- Conclusion The autophagic abilities of macrophages were significantly enhanced when the cells removed the apoptotic lymphocytes. 结论 巨噬细胞清除凋亡淋巴细胞时自噬功能显著增强。
- Conclusion The chorion and decidua have autophagic apoptotic tendency during termination of early pregnancy by mifepristone,together with disintegration of the reticular fibers. 结论米非司酮药物流产时,绒毛膜及蜕膜细胞均呈现一种自噬性凋亡倾向,同时释放大量松弛素,引起网状纤维溶解、断裂,蜕膜组织崩解、剥脱。
- Moreover the conserved Gly120 residues of rat LC3A and LC3B are also essential for their characteristic C-terminal cleavage and localization to autophagic membranes. 而且羧基末端保守的甘氨酸(Gly120)是大鼠LC3A和LC3B翻译后羧基末端切割和修饰,以及自噬体膜定位所必须的。
- When compared with the control group, numbers of autophagic cells and autophagosomes in these cells increase in the group of macrophages that engulfed the apoptotic cells. 结果 巨噬细胞活跃地吞噬凋亡淋巴细胞、凋亡细胞核、凋亡小体或其他细胞碎片,形成异噬体。
- Additionally, we found rat LC3A and LC3B, two novel isoforms of rat LC3, undergo the same post-translational modifications and localize to autophagic membranes as rat LC3. 发现大鼠LC3A和LC3B经过了与大鼠LC3相同的翻译后羧基末端切割和修饰反应,并且都能定位到自噬体膜上。
- Objective To study the exist of Taxol-induced autophagy and autophagic cell death in SGC-7901/BGC-823 cell lines, and to study the role to the sensibility of apoptosis induced by Taxol. 目的明确自噬和自噬性细胞死亡在胃癌SGC-7901及BGC-823细胞紫杉醇处理过程中的存在,探讨其对紫杉醇诱导的凋亡敏感性的作用。
- In the course of L02 autophagic apoptosis induced by VCR the autophagicstage is prior to executional stage of apoptosis, and run through the wholecourse of autophagic apoptosis of L02 cells. VCR诱导的L02细胞自噬性凋亡过程中自噬阶段早于凋亡执行阶段,并贯穿了整个凋亡过程。
- Therefore, the protein levels and redistribution of ATG5-ATG12 and/or LC3-II conjugates in the membrane fractions are often used as a measure to determine autophagic activity (Kabeya et al, 2004). 膜成分中ATG5-ATG12 和/或LC3-II 连接体的蛋白水平和再分布通常被用来衡量自噬活力。
- As blockage of CMA increases cellular vulnerability to stressors, we propose that dopamine-induced autophagic inhibition could explain the selective degeneration of PD dopaminergic neurons. 由于CMA的阻断增加了细胞对应激原的易损性,我们认为多巴胺诱导的自噬抑制可以解释PD多巴胺能神经元的选择性变性。