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- Result Nicardipine can induce rat mesangial cell apoptosis in vivo. 结论尼卡地平在体内有诱导大鼠系膜细胞凋亡的作用。
- Objective To study the effect of nicardipine on rat mesangial cell apoptosis in vivo. 目的探讨尼卡地平体内对大鼠系膜细胞凋亡的诱导作用。
- Mesangial cell nuclei showed irregular shape and mitochondria swelled, stroma was normal. 系膜细胞核不规则，胞质内线粒体肿胀．系膜基质正常。
- Objective To study the effect of L arginine/NOS pathway on LPS stimulated human renal mesangial cell proliferation. 目的:探讨L精氨酸/一氧化氮合酶途径在脂多糖(LPS)对人肾系膜细胞增殖中的作用。
- Endothelial and mesangial cells are normal in number. 内皮细胞和系膜细胞数目正常。
- We also studied the phenomenon of mesangial cell apoptosis by TUNEL and the expression of Bcl-2 and,Caspase-3 and Fas by immunohistochemistry SABC. TUNEL法检测系膜区细胞凋亡现象; 免疫组化SABC法检测Bcl-2、Caspase-3、Fas蛋白的表达情况。
- DCN-media ted transduction possibly by signaling molecule ERK1/2 and SAPK/JNK and p21 protein can suppress the cultured mesangial cell growth. DCN对肾MsC的生长有抑制作用,其机制可能经ERK1/2、SAPK/JNK和p21蛋白介导。
- Objective To study the effect of Shenshuning mixture on phenotypic modulation of mesangial cell in glomerulosclerosis rats and its mechanism. 目的观察中成药复方肾疏宁对肾小球硬化模型大鼠肾小球系膜细胞表型转化的作用,探讨肾疏宁防治肾小球硬化的作用机制。
- Conclusion Nicardipine can induce rat mesangial cell apoptosis in vivo, which may be a useful medicine in treating mesangial proliferative glomerulonephritis. 这可能是治疗系膜增生性肾小球肾炎的有效药物。
- Objective To explore the inhibitory effect of decorin(DCN) on rat mesangial cell (MsC) growth and on the expression of mitogen-activated protein kinases (MAPKs) and p21 protein. 目的探讨饰胶蛋白聚糖(DCN)对大鼠系膜细胞(MsC)生长的抑制作用及其信号转导分子MAPKs和p21表达的影响。
- The clear supernatant of rat macrophage cultivated in DMEM culture fluid containing 12.5 mol/L glucose could markedly promote the hyperplasia of mesangial cell(P<0.01). 大鼠巨噬细胞在含12.;5mol/L葡萄糖的DMEM培养液中培养24h;其上清明显促进系膜细胞增殖的(P<0
- Objective To study the effects of acyl-coenzyme A cholesterol acyltransferase inhibitor(ACATI, 58-035) on cholesterol homeostasis in lipid-loaded human mesangial cell line(HMCL) . 摘要 目的 研究酰基辅酶A胆固醇酰基转移酶抑制剂（ACATI，58-035）对脂质负荷人系膜细胞系（HMCL）细胞内脂质稳态的影响。
- To explore the intensity of inhibitory function of Shenkang injection (SKI), a Chinese herbal recipe, and benazepril on the proliferation of human glomerular mesangial cell (MC). 目的:探讨肾康注射液与苯那普利对人肾小球系膜细胞(MC)增殖的不同抑制作用强度。
- Anti-mesiangial cell antibodies could directly interact with antigens located on mesangial cell membrane and form in situ immune complexes in renal mesangium. 结论 1.;部分抗肾小球系膜细胞抗体与抗DNA抗体无关，提示抗DNA抗体以外的直接针对肾小球系膜细胞的自身抗体可能在狼疮肾炎的发病中起一定作用。
- The activation of PTK/transcription activator signaling cascades can stimulate the excessive proliferation of mesangial cell proliferation and then result in diabetic nephropathy. 蛋白酪氨酸激酶/转录激活子途径信号级联放大的激活刺激肾小球膜细胞过度增殖，导致糖尿病肾病。
- Moreover, mesangial cells possess phagocytosis, production of various bioactive substances and so on. 此外，系膜细胞还有吞噬及产生并分泌多种生物活性物质等功能。
- The normal mesangium contains about 2 to 4 mesangial cells, which have a macrophage-like function. 正常的肾小球膜包含大约2到4个肾小球细胞，有类似巨噬细胞的作用。
- Method:Using serumpharmacological test of Chinese medicinal herbs,we observed that how did SKI stimulates endothelin 1(ET 1) and nitric oxide(NO) secretion in cultured human glomerular mesangial cell(GMC). 方法 :采用放射免疫检测技术 ,观察SKI对体外培养人肾小球系膜细胞 (GMC)自分泌内皮素 1(ET 1)、一氧化氮 (NO)水平的影响。
- Methods:The mesangial cell line was treated by valsartan and low molecular weight heparin under different concentrations and times,and the proliferation activity was measured by MTT. 方法:采用MTT比色法,观察缬沙坦和低分子量肝素不同作用时间和不同作用浓度以及二者合用时对高糖刺激系膜细胞增殖的影响。
- Floege J, Eng E, Yong BA, et al. Heparin suppresses mesangial cell proliferation and ma?鄄trix expansion in experimental mesangioproliferative glomerulonephritis. Kidney Int,1993,43:369-380. 张佶，谌贻璞，等。低分子肝素对肾小球系膜细胞及细胞外基质作用的研究中华肾脏病杂志2001，17（2）27-30。
